UniProt Accession

 CAV3_RAT; P51638 

Genbank Protein ID

 U31968; BC084692 

Genbank Nucleotide ID

 AAC52377.1; AAH84692.1 

Protein Name

 Caveolin-3 

Protein Synonyms/Alias

  

Gene Name

 Cav3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
15	DLEARIIKDIHCKEI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). 

Sequence Annotation

 CROSSLNK 38 38 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Cell membrane; Complete proteome; Golgi apparatus; Isopeptide bond; Membrane; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IDA:BHF-UCL.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:RGD.
 GO:0031594; C:neuromuscular junction; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0031982; C:vesicle; IDA:BHF-UCL.
 GO:0005246; F:calcium channel regulator activity; IEA:Compara.
 GO:0032947; F:protein complex scaffold; IDA:RGD.
 GO:0017080; F:sodium channel regulator activity; IEA:Compara.
 GO:0007015; P:actin filament organization; IEA:Compara.
 GO:0055013; P:cardiac muscle cell development; IEA:Compara.
 GO:0070836; P:caveola assembly; IEA:Compara.
 GO:0030154; P:cell differentiation; IEP:RGD.
 GO:0016049; P:cell growth; IEP:RGD.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0031122; P:cytoplasmic microtubule organization; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.
 GO:0090002; P:establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0060347; P:heart trabecula formation; IEA:Compara.
 GO:0046716; P:muscle cell homeostasis; IEA:Compara.
 GO:0007520; P:myoblast fusion; IEA:Compara.
 GO:0051926; P:negative regulation of calcium ion transport; IEA:Compara.
 GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; IMP:RGD.
 GO:0045792; P:negative regulation of cell size; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IEA:Compara.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0060299; P:negative regulation of sarcomere organization; IEA:Compara.
 GO:0051647; P:nucleus localization; IEA:Compara.
 GO:0001778; P:plasma membrane repair; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO:0031116; P:positive regulation of microtubule polymerization; IMP:RGD.
 GO:0010831; P:positive regulation of myotube differentiation; IEA:Compara.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0090279; P:regulation of calcium ion import; IEA:Compara.
 GO:1901019; P:regulation of calcium ion transmembrane transporter activity; IEA:Compara.
 GO:0055117; P:regulation of cardiac muscle contraction; IEA:Compara.
 GO:0008016; P:regulation of heart contraction; IMP:RGD.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:1900825; P:regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; IEA:Compara.
 GO:0051394; P:regulation of nerve growth factor receptor activity; IEA:Compara.
 GO:1900744; P:regulation of p38MAPK cascade; IEA:Compara.
 GO:0051896; P:regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0038009; P:regulation of signal transduction by receptor internalization; IEA:Compara.
 GO:0014819; P:regulation of skeletal muscle contraction; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Compara.
 GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Compara.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara. 

Interpro

 IPR001612; Caveolin.
 IPR018361; Caveolin_CS. 

Pfam

 PF01146; Caveolin 

SMART

  

PROSITE

 PS01210; CAVEOLIN 

PRINTS