UniProt Accession

 ASB6_HUMAN; Q9NWX5; Q5SZB7; Q9BV15 

Genbank Protein ID

 AK000555; AK023004; AL590369; AL590369; CH471090; CH471090; BC001719; BC065913 

Genbank Nucleotide ID

 BAA91250.1; BAB14355.1; CAI14509.1; CAI14510.1; EAW87899.1; EAW87900.1; AAH01719.1; AAH65913.1 

Protein Name

 Ankyrin repeat and SOCS box protein 6 

Protein Synonyms/Alias

 ASB-6 

Gene Name

 ASB6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	LTELLERKAHSPFYQ	ubiquitination	[1, 2, 3]
75	GVSNALLKMAELGLT	ubiquitination	[2]
397	WPVDVKVKALPLPDR	ubiquitination	[2]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 REPEAT 67 97 ANK 1.
 REPEAT 102 131 ANK 2.
 REPEAT 136 166 ANK 3.
 REPEAT 170 205 ANK 4.
 REPEAT 226 255 ANK 5.
 REPEAT 260 289 ANK 6.
 DOMAIN 360 415 SOCS box.  

Keyword

 Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 421 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001496; SOCS_C. 

Pfam

 PF12796; Ank_2
 PF07525; SOCS_box 

SMART

 SM00248; ANK
 SM00969; SOCS_box 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50225; SOCS 

PRINTS