UniProt Accession

 E9PI38_HUMAN; E9PI38 

Genbank Protein ID

 AP001362 

Genbank Nucleotide ID

  

Protein Name

 Transcription factor p65 

Protein Synonyms/Alias

  

Gene Name

 RELA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	NLGIQCVKKRDLEQA	acetylation	[1]
164	APNTAELKICRVNRN	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0006117; P:acetaldehyde metabolic process; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0006952; P:defense response; IEA:Compara.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Compara.
 GO:0042177; P:negative regulation of protein catabolic process; IEA:Compara.
 GO:0009887; P:organ morphogenesis; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Compara.
 GO:0014040; P:positive regulation of Schwann cell differentiation; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0050727; P:regulation of inflammatory response; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0033590; P:response to cobalamin; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0043278; P:response to morphine; IEA:Compara.
 GO:0032495; P:response to muramyl dipeptide; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara. 

Interpro

 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR000451; NF_Rel_Dor.
 IPR008967; p53-like_TF_DNA-bd.
 IPR011539; RHD. 

Pfam

 PF00554; RHD 

SMART

  

PROSITE

 PS01204; REL_1
 PS50254; REL_2 

PRINTS

 PR00057; NFKBTNSCPFCT.