Tag | Content |
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CPLM ID | CPLM-015233 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tubulin alpha-1B chain |
Protein Synonyms/Alias | Alpha-tubulin 2; Tubulin alpha-2 chain |
Gene Name | Tuba1b |
Gene Synonyms/Alias | Tuba2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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336 | NAAIATIKTKRSIQF | ubiquitination | [1] | 338 | AIATIKTKRSIQFVD | ubiquitination | [1] |
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Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
Sequence Annotation | NP_BIND 142 148 GTP (Potential). MOD_RES 40 40 N6-acetyllysine (By similarity). MOD_RES 41 41 Phosphothreonine (By similarity). MOD_RES 48 48 Phosphoserine (By similarity). MOD_RES 232 232 Phosphoserine (By similarity). MOD_RES 334 334 Phosphothreonine (By similarity). MOD_RES 339 339 Omega-N-methylarginine (By similarity). MOD_RES 340 340 Phosphoserine (By similarity). MOD_RES 432 432 Phosphotyrosine (By similarity). MOD_RES 439 439 Phosphoserine (By similarity). MOD_RES 451 451 Phosphotyrosine (By similarity). CROSSLNK 326 326 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 370 370 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Isopeptide bond; Methylation; Microtubule; Nucleotide-binding; Phosphoprotein; Reference proteome; S-nitrosylation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 451 AA |
Protein Sequence | MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK 60 HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD 120 RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 180 VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA 240 SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN 300 QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRS IQFVDWCPTG FKVGINYQPP 360 TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 420 AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y 451 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro. GO:0007017; P:microtubule-based process; IEA:InterPro. GO:0051258; P:protein polymerization; IEA:InterPro. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |