CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013264
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C2 domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 C2CD3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
86DALQTEPKAVRTTTRubiquitination[1]
279LKGRAPRKQMSLLNSubiquitination[1]
298PQIRTVAKSHSDSCIubiquitination[1]
326ALLEQGNKLRNAMVIubiquitination[1, 2]
373AFSRNRFKDHIEDHLubiquitination[1]
615SSKITDGKVKFQQRFubiquitination[2]
1700QQQSRLSKELLLDPQubiquitination[1]
1772LESLIHFKEERQARRubiquitination[1, 2]
1785RRGVETSKSLIPIYSubiquitination[1]
1823QLAHASSKELDFSSPubiquitination[1]
1888SILTSLRKNLSELDQubiquitination[1]
1984RARSRSNKATTLPDAubiquitination[1, 2, 3]
2227DSADSFKKLPLNLASubiquitination[1]
2352FSSQYSQKD******ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 DOMAIN 1163 1289 C2 1.
 DOMAIN 1622 1728 C2 2.
 MOD_RES 2114 2114 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2353 AA 
Protein Sequence
MKQRKGQGSG GSRGRKKRGL SDISPSTSLP PLVEGQLRCF LKLTVNRVIW KIAKPPTCVL 60
VRVRWWGETS DGTLFCPRDA LQTEPKAVRT TTRYAIRCGP KQFTSYLTDM AVLVLEVITK 120
LDGLPIGRVQ INGLAQLSPT HQINGFFTIV SSTSKKLGEL QVSLALEPLS ETYDSYHPLP 180
TTDMTENVLL SKQGFRENTE PSSTQFQVPS RPRDIHTIKI DGKELAANSS RSTTPRGKDH 240
VCFAENPDTI KDSSFGLQHS LNSGQSLESV TLKGRAPRKQ MSLLNSSEFQ PQIRTVAKSH 300
SDSCILSSNN LPTKDLLSAL LEQGNKLRNA MVISAMKSSP ETSMLLDQVH PPINEDSLRA 360
STQIRAFSRN RFKDHIEDHL LPSTENTFWR HDTKADTRAI QLLLGSAELS QGNFWDGLGS 420
PPDSPSPGSD VYCISELNDP QYDQSLLENL FYTAPKSDTS ISDFLSEEDD IVPSKKISQS 480
TALARSSKVL ESSDHKLKKR SAGKRNRNLV EQQMLSETPE DAQTMTLSVD RLALLGRTHS 540
VRIIIETMGV PPDSPQMTPG KKSYAGPPPK VTTAKKRTFF VEYHFPVGFS ESGLGKTALI 600
TEVVRLASSK ITDGKVKFQQ RFVFPVQFGG PMIEHWWNSN LTFQIYVKKT PQKKPEVIGS 660
VSLSLRAVIQ SELLSFSDQL PVQQENGQSP FGPLKVTMEL ITDNKDFTGI NTKLSGNTHY 720
TPLCAPTSPN KALPELNQDM TCTKNPQNLN QIHEETAKKA QNLVLPNRKS PSPVAPHPST 780
FVATPASHNL VNQTNGTTKE SALLLHVLLM VPDGKDFISG ESEKQSPCNV YLNCKLFSTE 840
EVTRSVIAWG TTQPVFNFSQ VIPVSLSSKY LERLKNNVMV IETWNKVRSP GQDKLLGLVK 900
LPLHQFYMSF KDAKISRLLL DAQYPVVAVD SYMPVIDVFS GHQNGSLRVF LAMGSSNQIM 960
ALQRLKNEEG TLPPFSPRPA HFLDQPTAAS VAMAEDRGNG LMEHCFEIHI EMVKGLAPLQ 1020
ATVWGEADCY VQYYFPVQHS QSSVLKGPEF LENGITLKPF RTATTLCVPD PIFNSEHHHS 1080
LLLPAEVPVQ RLLLSAFSAQ GLVPGGGVQF EIWCRYYYPN VRDQKVAKGT LPLSRICAMV 1140
TTQHREDVGI QTFNLPLTPR IENRKELRNQ SSGLLDVGLR YRRSPRTAEG VLAARTVSIS 1200
VQIIRACGLQ AAAKALAERE PALQFSATVG VNASVTTHLS FLPQGEQRRT HPVACSFCPE 1260
FSHHVEFTCN LVTQHCSGEA CFLAELLEFA EVIFAVYHEN TKSASDIISI ESCKEYLLGV 1320
VKVPTKELLI KRSGITGWYP IILPEDGGLP HGLELMQKIV GGLELSISFT HRGDRERVLE 1380
AAEHLGWSFE NSLKDFVRMD EGEPATVTIS TPRLWLPIHC VLLAGHNHIH KNTYCYLRYK 1440
FYDHEAFWTP LKKPKESVNK KQIMVTFKAS KRAEVTRGPS LLWYFREERL EIQVWRAYGN 1500
DSVERPHQTD SWIGSAYVDL ARLGERSART LTVSGVYPLF GRNASNLSGA ALRVHVVLSS 1560
LSSHLEPTHE LDSMDCSSHS ESEQLPRRND EVQLSPPEVI SCHQKSPAST QVPCSSTTAE 1620
VRLTQEGPAD LDGTFAVSIL VERAMHLSLK GSPLTERKVS IPSCCVSFAT ADESSPVYTQ 1680
VVENTDSPIW NFQQQSRLSK ELLLDPQQTL VFKVWHKGDE ERVIGFASVD LSPLLSGFQF 1740
VCGWYNITDF SGECQGQIKV AVSPLESLIH FKEERQARRG VETSKSLIPI YSPFSFPASD 1800
TYAAFSSHMA RQTLDQLAHA SSKELDFSSP GRSDTTRSQA SRHEEHVQNI RRFHESLHLQ 1860
GEAPLPCDDK LTTSPLSSQT SILTSLRKNL SELDQIQRYF RQKLTKPFLP LSPQTQTAIS 1920
QHQESCRDHL GPGASSLDPG SQCILEKSSN LVLQVSSLIT DLQTITRDSQ AALSSHRARS 1980
RSNKATTLPD AQDTEALQER CTMPDEPLVR APDKGTDSPS PPPLEETSNG GRMLHESLRH 2040
AVPITRMQSS EDTEAGPAYS DEDYEEDIIE PRTLNEITTV TDKTSPWSSV ISDTSEVISP 2100
QPDEVQREGP SCPSPGPFCR EELMVKSSFL SSPERAVNPH LPRQGSPSQS LVACECEASK 2160
ARVGGESASA NPQPIPCPTL SGAQQSSTFV GWSSPQTDQN KEPKSEAPAE NEAATSELGD 2220
SADSFKKLPL NLASQSRREN HKGPPIDSSD IRQRQVTTGS ETSTKQSLLL PGPIVVPNFF 2280
LPPQQLEASL RMLSLSATLP PAATTDQDKS EATRGALSQR PCRPRPNSLP LNLPEEETLR 2340
IARIFSSQYS QKD 2353 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005932; C:microtubule basal body; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0001947; P:heart looping; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0021997; P:neural plate axis specification; IEA:Compara.
 GO:0021915; P:neural tube development; IEA:Compara.
 GO:0016485; P:protein processing; IEA:Compara.
 GO:0030162; P:regulation of proteolysis; IEA:Compara.
 GO:0008589; P:regulation of smoothened signaling pathway; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS