UniProt Accession

 EXOC7_HUMAN; Q9UPT5; B5MC69; B8XXP2; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32 

Genbank Protein ID

 FJ457119; FJ457120; AB028990; AK022397; AK022552; AK023832; AL834324; AC018665; BC011045; BC018466 

Genbank Nucleotide ID

 ACK36853.1; ACK36854.1; BAA83019.1; BAB14026.1; BAB14095.1; BAB14694.1; CAD38992.2; AAH11045.1; AAH18466.1 

Protein Name

 Exocyst complex component 7 

Protein Synonyms/Alias

 Exocyst complex component Exo70 

Gene Name

 EXOC7 

Gene Synonyms/Alias

 EXO70; KIAA1067 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	EKSDQLTKNMVSILS	ubiquitination	[1, 2]
55	SFESRLMKLENSIIP	ubiquitination	[3]
65	NSIIPVHKQTENLQR	ubiquitination	[1, 2, 3]
118	EYLGSMAKIQKAVEY	ubiquitination	[4]
121	GSMAKIQKAVEYFQD	ubiquitination	[4]
138	PDSPELNKVKLLFER	ubiquitination	[4, 5]
140	SPELNKVKLLFERGK	ubiquitination	[4]
147	KLLFERGKEALESEF	ubiquitination	[4]
653	DKERQIIKERFKGFN	ubiquitination	[4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Exocytosis; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 735 AA 

Protein Sequence

Gene Ontology

 GO:0034451; C:centriolar satellite; IDA:BHF-UCL.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0000145; C:exocyst; IEA:InterPro.
 GO:0032584; C:growth cone membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR016159; Cullin_repeat-like_dom.
 IPR004140; Exo70. 

Pfam

 PF03081; Exo70 

SMART

  

PROSITE

  

PRINTS