CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022654
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-adducin 
Protein Synonyms/Alias
 Adducin-like protein 70 
Gene Name
 Add3 
Gene Synonyms/Alias
 Addl 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
21PPPSMPHKERYFDRIubiquitination[1]
401VREKPRHKSDVEIPAubiquitination[1]
426SAPLSPLKFMAQRQQubiquitination[1]
484VSSGTPIKIEDPNQFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. 
Sequence Annotation
 REGION 684 701 Interaction with calmodulin (Potential).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 42 42 Phosphoserine (By similarity).
 MOD_RES 64 64 Phosphoserine (By similarity).
 MOD_RES 402 402 Phosphoserine.
 MOD_RES 423 423 Phosphoserine (By similarity).
 MOD_RES 442 442 Phosphoserine (By similarity).
 MOD_RES 673 673 Phosphoserine.
 MOD_RES 677 677 Phosphoserine.
 MOD_RES 681 681 Phosphoserine.
 MOD_RES 683 683 Phosphoserine; by PKC (By similarity).  
Keyword
 Acetylation; Actin-binding; Alternative splicing; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MSSDTSPAVV TTPPPPSMPH KERYFDRINE SDPEYLRERN MSPDLRQDFN MMEQRKRVTQ 60
ILQSPAFRED LECLIQEQMK KGHNPSGLLA LQQIADYIVT SSFSGFSSPS LSLGMVTPIN 120
DLPGADTSSY VKGEKLTRCK LASLYRLADL FGWAHLANTY ISVRISKEQD HIIIIPRGLS 180
FSEATASTLV KVNIIGEVVD QGSTDLKIDH TGFSPHAAIY STRPDVKCVI HIHTLATAAV 240
SSMKCGILPI SQESLILGDV AYYDYQGSLD EEEERIELQK VLGPSCKVLV LRNHGMVALG 300
ETLEEAFHYI FNVQMACEIQ VQAVAGAGGV DNLLVLDLQK YKAFTHGVAM SGGGGVNMAS 360
HQKWKVGEIE FEGLMRTLDN LGYRTGYAYR HPLVREKPRH KSDVEIPATV TAFSFEDDSA 420
PLSPLKFMAQ RQQREKTRWL NSPNTYMKVN VPEESRNGET SPRTKITWMK AEDSSKVSSG 480
TPIKIEDPNQ FVPLNTNPTE VLEKRNKIRE QNRYDLKTAG PQSQLLAGIV VDKPPSTMQF 540
DDDDQGPPAP PNPFSHLLEG ELEEYTKTIE RKQQGLDDAE QGSLSDDAAS VSQIQSQTQS 600
PQSVPERLEE NHELFSKSFT SMDAPVMIMN GKDEMHDVED ELAQRVSRLT TSTTIENIEI 660
TIKSPERTEE VLSPDGSPSK SPSKKKKKFR TPSFLKKNKK KEKVEA 706 
Gene Ontology
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005911; C:cell-cell junction; IDA:MGI.
 GO:0000794; C:condensed nuclear chromosome; IDA:MGI.
 GO:0005856; C:cytoskeleton; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IDA:MGI. 
Interpro
 IPR001303; Aldolase_II/adducin_N. 
Pfam
 PF00596; Aldolase_II 
SMART
 SM01007; Aldolase_II 
PROSITE
  
PRINTS