UniProt Accession

 CADM3_RAT; Q1WIM3 

Genbank Protein ID

 DQ272743 

Genbank Nucleotide ID

 ABB85362.1 

Protein Name

 Cell adhesion molecule 3 

Protein Synonyms/Alias

 Immunoglobulin superfamily member 4B; IgSF4B; Nectin-like protein 1; NECL-1 

Gene Name

 Cadm3 

Gene Synonyms/Alias

 Igsf4b; Necl1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
130	TVLGIPQKPIITGYK	acetylation	[1]
391	GQSGGDDKKEYFI**	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). 

Sequence Annotation

 DOMAIN 23 124 Ig-like V-type.
 DOMAIN 128 226 Ig-like C2-type 1.
 DOMAIN 231 313 Ig-like C2-type 2.
 CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
 DISULFID 48 108 By similarity.
 DISULFID 150 207 By similarity.
 DISULFID 252 297 By similarity.  

Keyword

 Calcium; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0007157; P:heterophilic cell-cell adhesion; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set.
 IPR003585; Neurexin-like. 

Pfam

 PF08205; C2-set_2
 PF07686; V-set 

SMART

 SM00294; 4.1m
 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50835; IG_LIKE 

PRINTS