Tag | Content |
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CPLM ID | CPLM-011705 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dynein heavy chain 14, axonemal |
Protein Synonyms/Alias | Axonemal beta dynein heavy chain 14; Ciliary dynein heavy chain 14 |
Gene Name | DNAH14 |
Gene Synonyms/Alias | C1orf67 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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185 | CLPRKSPKSLYNPYD | ubiquitination | [1] |
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Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). |
Sequence Annotation | NP_BIND 1164 1171 ATP (Potential). NP_BIND 1427 1434 ATP (Potential). MOTIF 1164 1171 GPAGTGKT motif (By similarity). CARBOHYD 1818 1818 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Glycoprotein; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3507 AA |
Protein Sequence | METFIPIDLT TENQEMDKEE TKTKPRLLRY EEKKYEDVKP LETQPAEIAE KETLEYKTVR 60 TFSESLKSEK TEDYLRESII QQHMVSPEPA SLKEKGKSRR KKDQTHACPN VRKARPVSYD 120 RTEPKDDDVI RNIIRLREKL GWQTILPQHS LKYGSSKIAI QKITLKKPLE DDGEFVYCLP 180 RKSPKSLYNP YDLQVVSAHT AKHCKEFWVI TASFISKVIN IVGSVKEVEL IPTLEWLSER 240 RHYYLLRQFK IFSDFRMNKA FVTWKLNVKR IKTEKSRSFL YHHLFLADDL FQTCLVYIRG 300 LCEDAINLKN YNDHENNLSA ICLVKLDSSR TYSLDEFCEE QLQQATQALK QLEDIRNKAI 360 SEMKSTFLKV AEKNEIKEYF ESKLSEDDTT HFKLPKYRRL LETFFKFVML VDYIFQELIR 420 QLMNTAVTLL LELFNGSAGM PFSVEKKNEN LIRTFKDNSF PTGKTTNDCE ELVDNSKLHA 480 ISVQKSEVKT DTDINEILNS VEVGKDLRKT YAPIFEVNLC LRIPAESDSS ENSKENFHES 540 DQCPEECVMF EDEMSENKDN CVKKHSSEEL LPKAKKSKEI SYNLEDIISD TEIETEFENK 600 YMYYEFPEFP TNLFIDPNRL EFSVKIQNML TNMEKCITTI TPLCQDPQLS IFIDLVSIMD 660 LPNKTGSIIH YKEQTRWPDC HILFETDPAY QNIIVNLLTI IGNSMGLVNA YSHKFIKYCT 720 MTEKAKIMSM KISSMGELTS KEFEAILNRF RNYFRHIVNM AIEKRIGIFN VVSLDYQSEC 780 LLYIDNVIHM SHTLIQSVIE KKNKNLLEVV ESSLQQLECD PTEIEEFLEH FIFLNAISSK 840 ISKLEKEFLT MSQLYSVAKH HQIHISEEQI AIFQVLLLKF SQLKSSMKLS KINKDTAITK 900 FRDNLEACIS GLHVDVGNLK AKIRTPLLLC AGTQVSTAME MIQTLSGEAA SLTNKAKAYS 960 HYQDCFSDSQ SHMHSVNVEE ITQIVLSEIS DIEGDLTLRK KLWEAQEEWK RASWEWRNSS 1020 LQSIDVESVQ RNVSKLMHII SVLEKGLPKS DMVTHLKQVV TEFKQELPII IALGNPCLKP 1080 RHWEALQEII GKSVPLDKNC KVENLLALKM FQYENEINDM STSATNEAAL EKMLFKIIDF 1140 WNTTPLPLIL HHTEIYSIFI IPSIDDISAQ LEESQVILAT IKGSPHIGPI KDLVNEWDQN 1200 LTLFSYTLEE WMNCQRNWLY LEPVFHSSEI RRQLPAETEL FSQVISMWKK IMSKIQNKQN 1260 ALQITTSAGV LEILQNCNIH LEHIKKSLED YLEVKRLIFP RFYFLSNAEL LDILADSRNP 1320 ESVQPHLVKC FENIKQLLIW KQDIGPPAVK MLISAEGEGL VLPKKIRVRS AVEQWLVNVE 1380 KSMFDVLKKE RYIYNIILLF QSQIMFYNDC VKSFVSSYSR EKLEKVHAGL MCHLEEVADL 1440 VVLDTSNSRT KAILGALLIL YVHCRDIVIN LLLKNIFNAE DFEWTRHLQY KWNEKQKLCY 1500 VSQGNASFTY GYEYLGCTSR LVITPLTDRC WLTLMEALHL NLGGCPAGPA GTGKTETVKD 1560 LAKSLGKHCV VFNCFEDLDY KIVRKFFFGL VQSGAWSCFD EFNLIDLEVL SVIASQILTI 1620 KAAKDNYSAR FVLEGKEIRI NMSCAVFITM NPRYGGGVEL PDNLKSLFRP VAMMVPHYQM 1680 IAEIILFSFG FKSANSLSGK LTNLYELARK QLSQQDHYNF GLRSLKIVLI MAGTKKREFK 1740 CLSEADETLI VIEAIREASL PKCPPEDVPL FENIIGDIFP EVTVLKVNQL ALEKVIYTAT 1800 QQLGLQNWSS QKEKIIQFYN QLQVCVGVML VGPTGGGKTT VRRILEKALT LLPIADFLSV 1860 AERKSASKIS ERKGKVDICV LNPKCVTLSE LYGQLDPNTM EWTDGLLSAT IRSYVYFNTP 1920 KNTKKDIDLR LKSRISDLSN VFKLDSSDTT ETDDNIFEEI EKVVKIPENH NFDWQWIILD 1980 GPVDTFWVEN LNSVLDDTRT LCLANSERIA LTNKIRVIFE VDNLSQASPA TVSRCAMVYM 2040 DPVDLGWEPY VKSWLLKTSK IISQSGVDCL EFMIKNSVTD GLQFIRNRQK FQPYPMEDIT 2100 VVITLCRILD AFFDFMGKNG GFEQSDDLND TSSKEANSQR ESVTFKDIEK RDENTWYPEK 2160 NPDKLTKIIQ KLFVFAFTWA FGGALNREDE HRENIPFCPS LEPDSLAKVT YDFDKLVHEL 2220 FGNSSQVGWK HWGQSQGRRR KGNCINLPTG ECSIFGYFVD IEQCEFIPWS DLVPNDQTLI 2280 QRGTSLLTNL QRSGGNFLKI TECGECINYT ATRDTTCLSF LMSLLLKNSC PVLLTGESGV 2340 GKTAAINQML EKLEGPGAFD IKHGSILGDT LLYSEIKKSS SLKQNITILI PETHKTATGS 2400 SDNPTKKPEV RTNKKLLKNN DHKGVVVSTI NFSTNVTAAK TKEMILKKLI RRTKDTLGAP 2460 KNNRILIFID DMNMPVSDMY GAQPPLELIR QLLDLGGVYD TEKNTWKNIQ DLSIVAACVP 2520 VVNDISPRLL KHFSMLVLPH PSQDILCTIF QAHLGIYFSI NNFTPEVQKS KDQIISCSLA 2580 IYHQVRQNML PTPTKCHYMF NLRDMFKLLL GLLQADRTVV NSKEMAALLF VHEATRVFHD 2640 RLIDFTDKSL FYRLLSRELE NCFQIGIDGC GKKTCATLAC YLTDNKLYRV PISHKCAYIE 2700 FKEVFKKVFI HAGLKGKPTV LMVPNLNIEQ DSFLEDLNYI ISSGRIPDLF ENVELDSIAM 2760 KIRYLTEQSG HMDNRQSLLS FFQKRIYKNL HIFVIMSPEG PSFRQNCRVY PSMISSCTID 2820 WYERWPEEAL LIVANSFLKE KVNFENRENL KEKLAPTCVQ IHKSMKDLNR KYFEETGRFY 2880 YTTPNSYLQF METFAHILRA REEEMQTKRD RFHMGLSTIL EATTLVTEMQ EELLILGPQV 2940 EQKTKETETL MEKLRKDSQV VEKVQMLVKQ DEEIVAEEVR IVEDYAQKTA NELKSVLPAF 3000 DKAIVALNAL DKADVAELRV YTRPPFLVLT VMNAVCILLQ KKPNWATAKL LLSETGFLKK 3060 LINLDKDSIP DKVFVKLKKI VTLPDFNPHK ISLVSVACCS LCQWVIALNN YHEVQKVVGP 3120 KQIQVAEAQN VLKIARQRLA EKQRGLQLVE EHLLFLQAAY KDTVAEKQLL ANRKTMASRR 3180 FQCASVLLTV LEDEKTRWQE TINQIDNKLE GILGDILLSA ACIVYSGILT PEFRQLIVNK 3240 WETFCIENGI SLSSKFSLIK VMAQKYEISR WHNQGLPHGQ YSVENAILIK NGQQWPLLID 3300 PHRQAHKWIR QMEGSRLQKL SIEDSNYTKK IENAMKTGGS VLLQNLLETL APGLKAILKK 3360 DIYQKKGHYF IRVGDAEFEY NSNFRLYLST EIDNPHFLPS VYNFVTMINF TVTFQGLQDQ 3420 LLSTVVTHEV PHLEDQRSKL LESISLDAIT LEELEEKTLN LLQKALGSIL DDDKIVDTLR 3480 KSKMTSNEIS KRIEATKKAE SEIQAIRKNY LPIATRGALL YFLVADLTQI NYMYQFSLDW 3540 FHQVFVSSVV SKSKEQEHSF KREKVSPKEV HEFISISKEP NLENEKNLLD KHIKSAIDML 3600 TKSIFKVVSS ALFNEDKLCF SFRLCTVIMQ NNANGNLIQD DIGFLPEEEW NIFLYSGILI 3660 NIKSALSQSR LTSTFEIGES QHLQWLSDSR WRQCQYVSTH LEPFSLLCKS LLSNVSQWDT 3720 FKNSKAVYSL ISTPFSSENA SLEENTKPPE ETELLNENKE TCNPINFPWE KLTSFQRLIL 3780 VKVLRPESLN NSVRKFITEK MGNKYLQRTG VNLKDAYKGS NARTPLILIQ THGIDLTNIL 3840 LRFAQELKGT THHVTIISLG RDQAAKAEDL ILKALTKTQQ WVFLQNCHLA TSFMPRLCTI 3900 VESFNSPNVT IDPEFRLWLS SKSYSSFPIP VLKKGLKIAV ESPQGLKSNL LQTFGCTGSG 3960 EVTEEIFENP DCGQWWKKLL FSLCFFNAVI NERKNYGILG WNIAYKFNSS DLGVAIKVLE 4020 NSLRGQPSIS WQALRYLIGE VIYGGRVIDN WDKRCLKTLL YKFCNPEVLK DDFSFSRSAS 4080 IKDYIHIIQS LPDDDLPEVL GIHPEAIRSC WETQGEKFIE NLIAMQPKTT TANLMIRPEQ 4140 SKDELVMEIL SDLLKRLPLT VEKEEIAVGT PSTLKSMMSS SIWESLSKNL KDHDPLIHCV 4200 LLTFLKQEIK RFDKLLFVIH KSLKDLQLAI KGEIILTQEL EEIFNSFLNM RVPTLWQKHA 4260 YRSCKPLSSW IDDLIQRLNF FNTWAKVAYT AIQRRYMRFV TVWKQSIPST SQKCKHPEDS 4320 ENNFFEGFPS RYWLPAFFFP QAFLAAVLQD YGRSRGIAVD ALTFTHHVIS NTTDKDEKFS 4380 VFMPKKLNIV RRAFKGSASS HTGVYIFGLF IEGARWNREQ KILEDSLPLE MCCDFPDIYF 4440 LPTKISTKTP NASNQTDSEL YAFECPVYQT PERSRILATT GLPTNFLTSV YLSTKKPPSH 4500 WITMRVALLC EKNEK 4515 |
Gene Ontology | GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell. GO:0030286; C:dynein complex; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003777; F:microtubule motor activity; IEA:InterPro. GO:0007018; P:microtubule-based movement; IEA:InterPro. |
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