| Tag | Content |
|---|
| CPLM ID | CPLM-006255 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 17 |
Protein Synonyms/Alias | Carboxypeptidase Y-deficient protein 21 |
Gene Name | VPS17 |
Gene Synonyms/Alias | PEP21; YOR132W; O3314; YOR3314W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 492 | SDTSQTLKGDSWTGE | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Plays a role in vesicular protein sorting. Required for the sorting and delivery of a subset of soluble vacuolar hydrolases. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation. |
Sequence Annotation | DOMAIN 108 227 PX.
MOD_RES 544 544 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 551 AA |
Protein Sequence | MTSAVPYDPY DDLDNNPFAE PQEEDSEPAA TTTDGSSSMS EERVGTEQTA ASVQDNGTAN 60
NIQNGLGEEG NATRSKTSNE HNENQQPSQP SERVILPERS DEKKKYTLLA KVTGLERFGS 120
ATGKKENPTI IFDCSTNLPT FRKQQYKNVK KSYEEFHQLF KYLNVAIQES FVPTLPSAYT 180
TFGINSEEDR MKVTRNFQLW FNRLSQDPLI IRNEEVAFFI ESDFNTYTPI NKSKSLASGL 240
KRKTLKQLAP PYDEITELAE FRPLVKSIYV VSQSLQEKLL RVSRNRKMMV QEENAFGQDF 300
VNLDEHNKLY RRYGKILTAV GDIDSIIATM DMATLYDGLE WIVRDAYAVK EALTNRHFIM 360
RNLVQAQQNS KAKQEQARRF RSRRDINPMK IDEALRQLKA AAKNEQVLTL KLQRITSNMI 420
IERKQWISWY EEWIRSSIKE FTLRKIEYER KKLTLLERVR SDIRKADENG GLSRLGRHAV 480
SNNNSDTSQT LKGDSWTGES NRKSQIPINK IAHTEFDDEL FTEDDGYNSQ DSDTTSLNAR 540
HAASLLGMST K 551 |
Gene Ontology | GO:0005768; C:endosome; IPI:SGD. GO:0030905; C:retromer complex, outer shell; IPI:SGD. GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD. GO:0007154; P:cell communication; IEA:InterPro. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0042147; P:retrograde transport, endosome to Golgi; IPI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |