CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037400
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disco-interacting protein 2 homolog A 
Protein Synonyms/Alias
  
Gene Name
 DIP2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
273VNSRVSSKIQQLLNTubiquitination[1]
282QQLLNTLKRPKRPPLubiquitination[1, 2, 3]
285LNTLKRPKRPPLKEFubiquitination[1]
290RPKRPPLKEFFVDDFubiquitination[4]
349RWGTTQPKSPCLTALubiquitination[1]
467ACQKGLPKAQTGEVAubiquitination[1]
519YIEYKTSKEGSTVGVubiquitination[1]
559LTNVLDFKRDAGLWHubiquitination[1, 5]
601IQKVCFYKARAALVKubiquitination[1]
915GIHISETKQRFLEGTubiquitination[6]
1297ALTQSFSKLFKDLGLubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1572 AA 
Protein Sequence
MADRGCPLEA APLPAEVRES LAELELELSE GDITQKGYEK KRAKLLARYI PLIQGIDPSL 60
QAENRIPGPS QTTAAAPKQQ KSRPTASRDE RFRSDVHTEA VQAALAKYKE RKMPMPSKRR 120
SVLVHSSVET YTPPDTSSAS EDEGSLRRPG RLTSTPLQSH SSVEPWLDRV IQGSSTSSSA 180
SSTSSHPGGR PTTAPSAAAT PGAAATTALA GLEAHTHIAD LHSAPPDVTT GLVEHSYFER 240
PQVASVRSVP RGCSGSMLET ADGVPVNSRV SSKIQQLLNT LKRPKRPPLK EFFVDDFEEL 300
LEVQQPDPNQ PKPEGSETSV LRGEPLTAGV PRPPSLLATL QRWGTTQPKS PCLTALDTTG 360
KAVYTLTYGK LWSRSLKLAY TLLNKLTSKN EPLLKPGDRV ALVFPNSDPV MFMVAFYGCL 420
LAELVPVPIE VPLTRKDAGS QQVGFLLGSC GVFLALTTDA CQKGLPKAQT GEVAAFKGWP 480
PLSWLVIDGK HLAKPPKDWH PLAQDTGTGT AYIEYKTSKE GSTVGVTVSH ASLLAQCRAL 540
TQACGYSEAE TLTNVLDFKR DAGLWHGVLT SVMNRMHVVS VPYALMKANP LSWIQKVCFY 600
KARAALVKSR DMHWSLLAQR GQRDVSLSSL RMLIVADGAN PWSISSCDAF LNVFQSRGLR 660
PEVICPCASS PEALTVAIRR PPDLGGPPPR KAVLSMNGLS YGVIRVDTEE KLSVLTVQDV 720
GQVMPGANVC VVKLEGTPYL CKTDEVGEIC VSSSATGTAY YGLLGITKNV FEAVPVTTGG 780
APIFDRPFTR TGLLGFIGPD NLVFIVGKLD GLMVTGVRRH NADDVVATAL AVEPMKFVYR 840
GRIAVFSVTV LHDDRIVLVA EQRPDASEED SFQWMSRVLQ AIDSIHQVGV YCLALVPANT 900
LPKAPLGGIH ISETKQRFLE GTLHPCNVLM CPHTCVTNLP KPRQKQPEVG PASMIVGNLV 960
AGKRIAQASG RELAHLEDSD QARKFLFLAD VLQWRAHTTP DHPLFLLLNA KGTVTSTATC 1020
VQLHKRAERV AAALMEKGRL SVGDHVALVY PPGVDLIAAF YGCLYCGCVP VTVRPPHPQN 1080
LGTTLPTVKM IVEVSKSACV LTTQAVTRLL RSKEAAAAVD IRTWPTILDT DDIPKKKIAS 1140
VFRPPSPDVL AYLDFSVSTT GILAGVKMSH AATSALCRSI KLQCELYPSR QIAICLDPYC 1200
GLGFALWCLC SVYSGHQSVL VPPLELESNV SLWLSAVSQY KARVTFCSYS VMEMCTKGLG 1260
AQTGVLRMKG VNLSCVRTCM VVAEERPRIA LTQSFSKLFK DLGLPARAVS TTFGCRVNVA 1320
ICLQGTAGPD PTTVYVDMRA LRHDRVRLVE RGSPHSLPLM ESGKILPGVK VIIAHTETKG 1380
PLGDSHLGEI WVSSPHNATG YYTVYGEEAL HADHFSARLS FGDTQTIWAR TGYLGFLRRT 1440
ELTDASGGRH DALYVVGSLD ETLELRGMRY HPIDIETSVI RAHRSIAECA VFTWTNLLVV 1500
VVELDGLEQD ALDLVALVTN VVLEEHYLVV GVVVIVDPGV IPINSRGEKQ RMHLRDGFLA 1560
DQLDPIYVAY NM 1572 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003824; F:catalytic activity; IEA:InterPro. 
Interpro
 IPR000873; AMP-dep_Synth/Lig.
 IPR010506; DMAP1-bd. 
Pfam
 PF00501; AMP-binding
 PF06464; DMAP_binding 
SMART
  
PROSITE
  
PRINTS