CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017187
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Epithelial splicing regulatory protein 2 
Protein Synonyms/Alias
 RNA-binding motif protein 35B; RNA-binding protein 35B 
Gene Name
 Esrp2 
Gene Synonyms/Alias
 Rbm35b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
231KPEVVKQKYETGPCSubiquitination[1]
239YETGPCSKADVVDNEubiquitination[1]
268QDVARFFKGLNIARGubiquitination[1]
321VRYIEVYKATGEEFVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). 
Sequence Annotation
 DOMAIN 247 343 RRM 1.
 DOMAIN 348 428 RRM 2.
 DOMAIN 465 545 RRM 3.  
Keyword
 Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 717 AA 
Protein Sequence
MTPPPPPPPP PGPDPAVDSA TDPCPEPQSL VVLFGATAGA LGPDLGSDET DLILLVWQVV 60
EPRSRQVGTL HKSLVRAEAA ALSPQCREAS GLSADSLARA ESLDKVLQQF SQLVSGDVAL 120
LGGGPYVLCT DGQQLLRQVL HPEASRKNLV LPDTFFSFYD LRREFHMQHP STCSARDLTV 180
GTMAQDLGLE TDATEDDFGV WEVKTMVAVI LHLLEGSNGQ LFSKPEVVKQ KYETGPCSKA 240
DVVDNETVVR ARGLPWQSSD QDVARFFKGL NIARGGVALC LNAQGRRNGE ALIRFVDSEQ 300
RDLALQRHKH HMGVRYIEVY KATGEEFVKI AGGTSLEVAR FLSREDQVIL RLRGLPFSAG 360
PTDVLGFLGP ECPVTGGADG LLFVRHPDGR PTGDAFALFA CEELAQAALR RHKGMLGKRY 420
IELFRSTAAE VQQVLNRYAA SPLLPTLTAP LLPIPFPLAG GTGRDCVRLR GLPYTATIED 480
ILSFLGEAAA DIRPHGVHMV LNQQGRPSGD AFIQMMSVER ALAAAQRCHK KMMKERYVEV 540
VPCSTEEMSR VLMGGSLSRS GLSPPPCKLP CLSPPTYATF QATPALIPTE TTALYPSSAL 600
LPAARVPAAA TPLAYYPGPA TQLYMNYTAY YPSPPVSPTT VGYLTTPPTA LASTPTTMLS 660
QPGALVRMQG VPYTAGMKDL LSVFQAYQLA PDDYTTLMPV GDPPRTVLQA PKEWVCL 717 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003729; F:mRNA binding; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR012337; RNaseH-like_dom.
 IPR000504; RRM_dom. 
Pfam
  
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS