UniProt Accession

 ALDH2_HUMAN; P05091; B4DW54; E7EUE5; Q03639; Q6IB13; Q6IV71 

Genbank Protein ID

 X05409; Y00109; M20456; M20444; M20445; M20446; M20447; M20448; M20449; M20450; M20451; M20452; M20453; M20454; AY621070; CR456991; AK301375; AC002996; AC003029; BC002967; BC071839; K03001; M26760; M54931 

Genbank Nucleotide ID

 CAA28990.1; CAA68290.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAA51693.1; AAT41621.1; CAG33272.1; BAG62916.1; AAH02967.1; AAH71839.1; AAB59500.1; AAA51694.1; AAA62825.1 

Protein Name

 Aldehyde dehydrogenase, mitochondrial 

Protein Synonyms/Alias

 ALDH class 2; ALDH-E2; ALDHI 

Gene Name

 ALDH2 

Gene Synonyms/Alias

 ALDM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
280	AAGSSNLKRVTLELG	ubiquitination	[1]
355	VGNPFDSKTEQGPQV	acetylation	[2]
355	VGNPFDSKTEQGPQV	ubiquitination	[1, 3]
368	QVDETQFKKILGYIN	ubiquitination	[1, 3]
428	VMQILKFKTIEEVVG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 NP_BIND 262 267 NAD (By similarity).
 ACT_SITE 285 285 Proton acceptor.
 ACT_SITE 319 319 Nucleophile.
 MOD_RES 368 368 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 517 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0004029; F:aldehyde dehydrogenase (NAD) activity; EXP:Reactome.
 GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; TAS:ProtInc.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0005975; P:carbohydrate metabolic process; TAS:ProtInc.
 GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006069; P:ethanol oxidation; TAS:Reactome.
 GO:0042136; P:neurotransmitter biosynthetic process; TAS:Reactome.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS