| Tag | Content |
|---|
| CPLM ID | CPLM-016661 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine carboxyl methyltransferase 2 |
Protein Synonyms/Alias | p21WAF1/CIP1 promoter-interacting protein; tRNA wybutosine-synthesizing protein 4 homolog; tRNA yW-synthesizing protein 4 homolog |
Gene Name | Lcmt2 |
Gene Synonyms/Alias | Kiaa0547; Tyw4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 455 | QLDLYKSKDNCSEGQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha- leucine ester residues. |
Sequence Annotation | REGION 161 162 S-adenosyl-L-methionine binding (By
BINDING 59 59 S-adenosyl-L-methionine (By similarity).
BINDING 89 89 S-adenosyl-L-methionine; via carbonyl
BINDING 114 114 S-adenosyl-L-methionine (By similarity).
BINDING 188 188 S-adenosyl-L-methionine; via carbonyl |
Keyword | Alternative splicing; Complete proteome; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 686 AA |
Protein Sequence | MGPRGRQRRA GTVQSTNDSS SLSKRSLAAH GYVRDPFAAL LVPGPVRRTP LIHRGYYVRA 60
RAVRHCVRAF LELTSALPSR TRAQILSLGS GSDSLYFRLK AAGLLARAAV WEVDFPDVSR 120
LKAERIEETP ELRAQTGPFK IGDSASSLCF ESADYRILGA DLRELQRLGE ALDGAGLDAT 180
SPTLLLAEAV LTYLEPSSAT ALIAWAAQRF PDALFVIYEQ MQPGDAFGQI MLQHFQRLHS 240
PLHGLELFPV VKAQRQRFLQ AGWTACSALD LNEFYRRLLS AEERQRVETL EPFDEYEEWH 300
LKCSHYFILA ASRGDILSET PVFEPSEASF QIDPASPSGF LSARVVTSDH QHSSLKRYGH 360
ASALLSPGVI FSAGGFGEQE GRHCRVSRFH VLSRSCDSEW EGCQISTLGT EGQWDGRLYH 420
TMTRLSDTRV LVLGGRLSPV SPASGALQLD LYKSKDNCSE GQNVTVTKAA LEEGSVLSCW 480
RHSTTEVYYQ NQRYLFVYGG RSVAEPVLSD CRFLHVETMA WVRIPVQGAS PEGRHSHSAC 540
SWQGGALIAG GLGASEELLS SVLFLKPVSS GFLWESIDIQ PSITPRYSHT AHVFNGKLLL 600
VGGVWIHSSS VPGVTVICLT TGLSSEYQID TASVPWPLML HNHSSALLPE EQQLLLIGGG 660
GNCFSFGTYF NPHTVALDLS SLRSGQ 686 |
Gene Ontology | GO:0003880; F:protein C-terminal carboxyl O-methyltransferase activity; ISA:MGI. GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. |
Interpro | |
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