CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017119
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Katanin p60 ATPase-containing subunit A-like 2 
Protein Synonyms/Alias
 Katanin p60 subunit A-like 2; p60 katanin-like 2 
Gene Name
 KATNAL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
263IIGLDAAKQLVKEAVubiquitination[1]
305TGKTLLAKAVATECKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays (By similarity). 
Sequence Annotation
 DOMAIN 25 57 LisH.
 NP_BIND 294 301 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Hydrolase; Microtubule; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 538 AA 
Protein Sequence
MELSYQTLKF THQAREACEM RTEARRKNLL ILISHYLTQE GYIDTANALE QETKLGLRRF 60
EVCDNIDLET ILMEYESYYF VKFQKYPKIV KKSSDTAENN LPQRSRGKTR RMMNDSCQNL 120
PKINQQRPRS KTTAGKTGDT KSLNKEHPNQ EVVDNTRLES ANFGLHISRI RKDSGEENAH 180
PRRGQIIDFQ GLLTDAIKGA TSELALNTFD HNPDPSERLL KPLSAFIGMN SEMRELAAVV 240
SRDIYLHNPN IKWNDIIGLD AAKQLVKEAV VYPIRYPQLF TGILSPWKGL LLYGPPGTGK 300
TLLAKAVATE CKTTFFNISA STIVSKWRGD SEKLVRVLFE LARYHAPSTI FLDELESVMS 360
QRGTASGGEH EGSLRMKTEL LVQMDGLARS EDLVFVLAAS NLPWELDCAM LRRLEKRILV 420
DLPSREARQA MIYHWLPPVS KSRALELHTE LEYSVLSQET EGYSGSDIKL VCREAAMRPV 480
RKIFDALENH QSESSDLPRI QLDIVTTADF LDVLTHTKPS AKNLAQRYSD WQREFESV 538 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:HAMAP.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008568; F:microtubule-severing ATPase activity; IEA:EC.
 GO:0051013; P:microtubule severing; IEA:HAMAP. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR027497; Katanin_p60_AL2.
 IPR006594; LisH_dimerisation.
 IPR013720; LisH_dimerisation_subgr.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA
 PF08513; LisH 
SMART
 SM00382; AAA
 SM00667; LisH 
PROSITE
 PS00674; AAA
 PS50896; LISH 
PRINTS