CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040187
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp34 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
455GTNSGTGKDLVFNTEacetylation[1]
1761CKTYTMDKQPLNTGEubiquitination[2]
1893FNMVTMMKEKVNTHFubiquitination[2]
1895MVTMMKEKVNTHFSFubiquitination[2]
2893FPCRENIKLIGGKSNubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3338 AA 
Protein Sequence
FYTIVCKIRI WLHIPAVMQH IIPFRTYVIR YLCKLSDQEL RQSAARNMAD LMWSTVKEPL 60
DTTLCFDKES LDLAFKYFMS PTLTMRLAGL SQITNQLHTF NDVCNNESLV SDTETSIAKE 120
LADWLISNNV VEHIFGPNLH IEIIKQCQVI LNFLAAEGRL STQHIDCIWA AAQLKHCSRY 180
IHDLFPSLIK NLDPVPLRHL LNLVSALEPG VHTEQTLYLA SMLIKALWNN ALAAKAQLSK 240
QSSFASLLNT NMPIGNKKEE EELRRAAPSP WSPAASPQSS DNSDTHQSGA SDIEMDEQLI 300
NRNKHVQQRL SDTEESMQGS SDETANSGED GSSGPGSSSG HSDGSSNEVN SSHASQSAGS 360
PGSEVQSEDI ADIEALKEEE EEEEEEEEEE EEEDDEEEED EEEDDDDDDD HGHNPAKNTC 420
GTELRNRKLE NPAGICLGES QGTSERNGTN SGTGKDLVFN TEPLPSVDNR IRMLDACAHS 480
EDPEHGISGE VSSAHLAQGS QEACITRSGD FLGETIGNEL FNCRQFIGPQ HHHHHHHHHH 540
HHHHHHHHHH HHHDGHMVDD MLSADDVSCS SSQVSAKSEK NMADFDGEES GCEEELVQIN 600
SHAELTSHLQ QHLPNLASIY HEHLSQGPAV HKHQFSSNAV TDINLDNVCK KGNTLLWDIV 660
QDDDAINLSE GLINEAEKLL CSLVCWFTDR QIRMRFIEGC LENLGNNRSV VISLRLLPKL 720
FGTFQQFGSS YDTHWITMWA EKELNMMKLF FDNLVYYIQG IREGRQKHAL YSHSAEVQVR 780
LQFLTCVFST LGSPDHFRLS LEQVDILWHC LVEDSECYDD ALHWFLNQVR SKDQHAMGME 840
TYKHLFLEKM PQLKPETISM TGLNLFQHLC NLARLATSAY DGGSNSELCG MDQFWGIALR 900
AQSGDVSRAA IQYINSYYIN GKTGLEKEQE FISKCMESLM IASSSLEQES HSSLTVIERG 960
LLMLKTHLEA FRRRFAYHLR QWQIEGTGIS SHLKALSDKQ SLPLRVVCQP AGLPDKMTIE 1020
MYPSDQVADL RAEVTHWYEN LQKEQINQQA QLQEFGQSSR KGEFPGGLMG PVRMISSGHE 1080
LTTDYDEKAL HELGFKDMQM VFVSLGAPRR ERKGEGVQLP ASCLPPPQKD NIPMLLLLQE 1140
PHLTTLFDLL EMLASFKPPS GKVAVDDSES LKCEELHLHA ENLSRRVWEL LMLLPTCPNM 1200
LTAFQNVSDE QSNDGLNWKE LLKIKSAHKL LYALEIIEAL GKPNRRIRRE STGSYSDLYP 1260
DSDDSSEDQV ENSKNSWTCK FVAAGGLQQL LEIFNSAILE PKEQESWTVW QLDCLACLLK 1320
LICQFAVDPS DLDLAYHDVF AWSGIAESHR KRTWPGKSRK AAGDHAKSLH IPRLTEVFLV 1380
LVQGTSLIQR LMSVAYTYDN LAPRVLKAQS DHRSRHEVSH YSMWLLVSWA HCCSLVKSSL 1440
ADSDHLQDWL KQLTLLIPET AVRHESCNGL YKLSLSGLDG GDSIHRSFLL LAASTLLKFL 1500
PDAQALKPPR IDDYEEEPLL KPGCKEYFWL LCKLVDNIHI KDASQTTLLD LDALARHLAD 1560
CIRSREILDH LDGSIEDDGL SGLLRLATSV IKHKPPFKFS REGQEFLRDI FNLLFLLPSL 1620
KDRRQPKCKS HSCRAAAYDL LVEMVKGSVE NYRLIHNWVM AQHMQSHAPY KWDYWPHEDV 1680
RAECRFVGLT NLGATCYLAS TIQQLYMIPE ARQAVFTAKY SEDMKHKTTL LELQKMFTYL 1740
MESECKAYNP RPFCKTYTMD KQPLNTGEQK DMTEFFTDLI TKVEEMSPEL KNTVKSLFGG 1800
VITNNVVSLD CEHVSQTAEE FYTVRCQVAD MKNIYESLDE VTIKDTLEGD NMYTCSHCGK 1860
KVRAEKRACF KKLPRILSFN TMRYTFNMVT MMKEKVNTHF SFPLRLDMTP YTEDFLMGKS 1920
DRKEGFKDVG DRSKDTESYE YDLIGVTVHT GTADGGHYYS FIRDIVNPHA YKNNKWYLFN 1980
DAEVKPFDSA QLASECFGGE MTTKTYDSVT DKFMDFSFEK THSAYMLFYK RMEPEEENGR 2040
EYKFDVSSEL LEWIWHDNMQ FLQDKNIFEH TYFGFMWQLC SCIPSTLPDP KAVSLMTAKL 2100
STSFVLETFI HSKEKPTMLQ WIELLTKQFN NSQAACEWFL DRMADDDWWP MQILIKCPNQ 2160
IVRQMFQRLC IHVIQRLRPV HAHLYLQPGM EDGSDDMDAS VEDIGGRSCV TRFVRTLLLI 2220
MEHGVKPHSK HLTEYFAFLY EFAKMGEEES QFLLSLQAIS TMVHFYMGTK GPENPQVEVL 2280
SEEEGEEEEE EEDILSLAEE KYRPAALEKM IALVALLVEQ SRSERHLTLS QTDMAALTGG 2340
KGFPFLFQHI RDGINIRQTC NLIFSLCRYN NRLAEHIVSM LFTSIAKLTP EAANPFFKLL 2400
TMLMEFAGGP PGMPPFASYI LQRIWEVIEY NPSQCLDWLA VQTPRNKLAH SWVLQNMENW 2460
VERFLLAHNY PRVRTSAAYL LVSLIPSNSF RQMFRSTRSL HIPTRDLPLS PDTTVVLHQV 2520
YNVLLGLLSR AKLYVDAAVH GTTKLVPYLS FMTYCLISKT EKLMFSTYFM DLWNLFQPKL 2580
SEPAIATNHN KQALLSFWYN VCADCPENIR LIVQNPVVTK NIAFNYILAD HDDQDVVLFN 2640
RGMLPAYYGI LRLCCEQSPA FTRQLASHQN IQWAFKNLTP HASQYPGAVE ELFNLMQLFI 2700
AQRPDMREEE LEDIKQFKKT TISCYLRCLD GRSCWTTLIS AFRILLESDE DRLLVVFNRG 2760
LILMTESFNT LHMMYHEATA CHVTGDLVEL LSIFLSVLKS TRPYLQRKDV KQALIQWQER 2820
IEFAHKLLTL LNSYSPPELR NACIDVLKEL VLLSPHDFLH TLVPFLQHNH CTYHHSNIPM 2880
SLGPYFPCRE NIKLIGGKSN IRPPRPELNM CLLPTMVETS KGKDDVYDRM LLDYFFSYHQ 2940
FIHLLCRVAI NCEKFTETLV KLSVLVAYEG LPLHLALFPK LWTELCQTQS AMSKNCIKLL 3000
CEDPVFAEYI KCILMDERTF LNNNIVYTFM THFLLKVQSQ VFSEANCASL ISTLITNLIN 3060
QYQNLQSDFT NRVEISKASA ALNGDLRALA LLLSVHTPKQ LNPALIPTLQ ELLNKCRTCL 3120
QQRNSLQEQE AKERKTKDDE GATPVKRRRV SSDEEHTVDS CIGDIKTETR EVLTPTSTSD 3180
NETRDSSIID PGTEQDLPSP ENSSVKEYRM EGPSSFSEDG SHIRSQHAEE QSNNGRFDDC 3240
KEFKDHCSKD TTLAEDESEF PSTSISAVLS DLADLRSCDG QALSSQDPEA AVSLSCGHSR 3300
GLISHMQQHD ILDTLCRTIE STIHVVTRIS GKGNQAAS 3338 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS