CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019929
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translation initiation factor eIF-2B subunit alpha 
Protein Synonyms/Alias
 eIF-2B GDP-GTP exchange factor subunit alpha 
Gene Name
 Eif2b1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
258KYKADTLKSVQTGQDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. 
Sequence Annotation
 MOD_RES 35 35 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Initiation factor; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 305 AA 
Protein Sequence
MEDGELIEYF KSQMKGDPKM ASAVAAIQTL LEFLKRDKGE TLQGLRANLT YAIKTLCGVD 60
SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGELF LRRISLSRNK IANLCHTFIK 120
DGARILTHAY SRVVLRVLEE AVAAKKRFSV YITESQPDLS GKKMAKALSH LNVPVTVVLD 180
AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP 240
LNQEDVPDKF KYKADTLKSV QTGQDLKEEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL 300
IKLYL 305 
Gene Ontology
 GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISO:MGI.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:Compara.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.
 GO:0032057; P:negative regulation of translational initiation in response to stress; IEA:Compara.
 GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
 GO:0006446; P:regulation of translational initiation; IBA:RefGenome.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0006413; P:translational initiation; ISS:UniProtKB. 
Interpro
 IPR000649; IF-2B-related. 
Pfam
 PF01008; IF-2B 
SMART
  
PROSITE
  
PRINTS