| Tag | Content |
|---|
| CPLM ID | CPLM-003547 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA topoisomerase 4 subunit A |
Protein Synonyms/Alias | Topoisomerase IV subunit A |
Gene Name | parC |
Gene Synonyms/Alias | b3019; JW2987 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 323 | FATTDLEKSYRINLN | acetylation | [1] | | 368 | RLNYRLEKVLKRLHI | acetylation | [1] | | 514 | MGWVRSAKGHDIDAP | acetylation | [1] | | 526 | DAPGLNYKAGDSFKA | acetylation | [1] | | 665 | SDLPQLSKGKGNKII | acetylation | [1] | | 716 | LRPEELQKVTGERGR | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation. |
Sequence Annotation | REGION 497 752 Sufficient for MukB binding.
ACT_SITE 120 120 O-(5'-phospho-DNA)-tyrosine intermediate |
Keyword | 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; DNA-binding; Isomerase; Membrane; Reference proteome; Topoisomerase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 752 AA |
Protein Sequence | MSDMAERLAL HEFTENAYLN YSMYVIMDRA LPFIGDGLKP VQRRIVYAMS ELGLNASAKF 60
KKSARTVGDV LGKYHPHGDS ACYEAMVLMA QPFSYRYPLV DGQGNWGAPD DPKSFAAMRY 120
TESRLSKYSE LLLSELGQGT ADWVPNFDGT LQEPKMLPAR LPNILLNGTT GIAVGMATDI 180
PPHNLREVAQ AAIALIDQPK TTLDQLLDIV QGPDYPTEAE IITSRAEIRK IYENGRGSVR 240
MRAVWKKEDG AVVISALPHQ VSGARVLEQI AAQMRNKKLP MVDDLRDESD HENPTRLVIV 300
PRSNRVDMDQ VMNHLFATTD LEKSYRINLN MIGLDGRPAV KNLLEILSEW LVFRRDTVRR 360
RLNYRLEKVL KRLHILEGLL VAFLNIDEVI EIIRNEDEPK PALMSRFGLT ETQAEAILEL 420
KLRHLAKLEE MKIRGEQSEL EKERDQLQGI LASERKMNNL LKKELQADAQ AYGDDRRSPL 480
QEREEAKAMS EHDMLPSEPV TIVLSQMGWV RSAKGHDIDA PGLNYKAGDS FKAAVKGKSN 540
QPVVFVDSTG RSYAIDPITL PSARGQGEPL TGKLTLPPGA TVDHMLMESD DQKLLMASDA 600
GYGFVCTFND LVARNRAGKA LITLPENAHV MPPVVIEDAS DMLLAITQAG RMLMFPVSDL 660
PQLSKGKGNK IINIPSAEAA RGEDGLAQLY VLPPQSTLTI HVGKRKIKLR PEELQKVTGE 720
RGRRGTLMRG LQRIDRVEID SPRRASSGDS EE 752 |
Gene Ontology | GO:0005694; C:chromosome; IEA:InterPro. GO:0005737; C:cytoplasm; IDA:EcoliWiki. GO:0009330; C:DNA topoisomerase complex (ATP-hydrolyzing); IDA:EcoliWiki. GO:0019897; C:extrinsic to plasma membrane; IDA:EcoliWiki. GO:0009295; C:nucleoid; IBA:RefGenome. GO:0005524; F:ATP binding; IEA:InterPro. GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IBA:RefGenome. GO:0006265; P:DNA topological change; IDA:EcoliWiki. GO:0030541; P:plasmid partitioning; IDA:EcoliWiki. GO:0007062; P:sister chromatid cohesion; IMP:EcoliWiki. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |