CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031054
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Diphthamide biosynthesis protein 1 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53QIPPEILKNPQLQAAubiquitination[1]
74NYNFEIPKTIWRIQQubiquitination[2]
271YRYDPYSKVLSREHYubiquitination[2]
298IATARSAKSWGLILGubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 453 AA 
Protein Sequence
MLERGHRQAL KRDPYSISIW LQPKTDTNSG LISILGRAPR GRVANQIPPE ILKNPQLQAA 60
IRVLPSNYNF EIPKTIWRIQ QAQAKKVALQ MPEGLLLFAC TIVDILERFT EAEVMVMGDV 120
TYGACCVDDF TARALGADFL VHYGHSCLIP MDTSAQDFRV LYVFVDIRID TTHLLDSLRL 180
TFPPATALAL VSTIQFVSTL QAAAQELKAE YRVSVPQCKP LSPGEILGCT SPRLSKEVEA 240
VVYLGDGRFH LESVMIANPN VPAYRYDPYS KVLSREHYDH QRMQAARQEA IATARSAKSW 300
GLILGTLGRQ GSPKILEHLE SRLRALGLSF VRLLLSEIFP SKLSLLPEVD VWVQVACPRL 360
SIDWSTAFPK PLLTPYEAAV ALRDISWQQP YPMDFYAGSS LGPWTVNHGQ GRRPHAPGRP 420
ARGKVQEGSA RPPSAVACED CSCRDEKVAP LAP 453 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0017183; P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine; IEA:InterPro. 
Interpro
 IPR002728; DPH1/DPH2.
 IPR016435; eu_DPH1/arc_DPH2. 
Pfam
 PF01866; Diphthamide_syn 
SMART
  
PROSITE
  
PRINTS