UniProt Accession

 DNJB2_HUMAN; P25686; A8K9P6; Q8IUK1; Q8IUK2; Q96F52 

Genbank Protein ID

 S37375; S37374; X63368; X63368; BT007088; AK292761; BC011609; BC047056 

Genbank Nucleotide ID

 AAA09034.1; AAA09035.1; CAA44968.2; CAA44969.2; AAP35751.1; BAF85450.1; AAH11609.1; AAH47056.1 

Protein Name

 DnaJ homolog subfamily B member 2 

Protein Synonyms/Alias

 DnaJ protein homolog 1; Heat shock 40 kDa protein 3; Heat shock protein J1; HSJ-1 

Gene Name

 DNAJB2 

Gene Synonyms/Alias

 HSJ1; HSPF3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	SASADDIKKAYRRKA	ubiquitination	[1]
34	ALQWHPDKNPDNKEF	ubiquitination	[1]
39	PDKNPDNKEFAEKKF	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

 DOMAIN 1 71 J.
 REPEAT 210 226 UIM 1.
 REPEAT 250 269 UIM 2.  

Keyword

 3D-structure; Alternative splicing; Chaperone; Complete proteome; Neurodegeneration; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 324 AA 

Protein Sequence

Gene Ontology

 GO:0016234; C:inclusion body; IDA:BHF-UCL.
 GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL.
 GO:0070628; F:proteasome binding; IDA:BHF-UCL.
 GO:0051082; F:unfolded protein binding; TAS:ProtInc.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0030433; P:ER-associated protein catabolic process; IDA:BHF-UCL.
 GO:0030308; P:negative regulation of cell growth; IGI:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IGI:UniProtKB.
 GO:0090084; P:negative regulation of inclusion body assembly; IDA:BHF-UCL.
 GO:0090086; P:negative regulation of protein deubiquitination; IDA:BHF-UCL.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
 GO:0031398; P:positive regulation of protein ubiquitination; IDA:BHF-UCL.
 GO:0006457; P:protein folding; TAS:ProtInc.
 GO:0006986; P:response to unfolded protein; TAS:ProtInc. 

Interpro

 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR003903; Ubiquitin-int_motif. 

Pfam

 PF00226; DnaJ 

SMART

 SM00271; DnaJ
 SM00726; UIM 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2
 PS50330; UIM 

PRINTS

 PR00625; JDOMAIN.