UniProt Accession

 PDCD2_HUMAN; Q16342; Q58HM9; Q58HN0; Q9UH12 

Genbank Protein ID

 S78085; AY948416; AY948417; AK297343; AL031259; BC008378 

Genbank Nucleotide ID

 AAB34865.1; AAX51225.1; AAX51226.1; BAG59795.1; CAA20285.1; AAH08378.1 

Protein Name

 Programmed cell death protein 2 

Protein Synonyms/Alias

 Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8 

Gene Name

 PDCD2 

Gene Synonyms/Alias

 RP8; ZMYND7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	RSEQFPSKVGGRPAW	ubiquitination	[1]
103	FRNQLPRKNDFYSYE	ubiquitination	[1]
129	ESVCLQLKSGAHLCR	ubiquitination	[1]
144	VCGCLGPKTCSRCHK	ubiquitination	[1]
157	HKAYYCSKEHQTLDW	ubiquitination	[1, 2]
243	REDKIFQKFKTQIAL	ubiquitination	[1]
245	DKIFQKFKTQIALEP	ubiquitination	[1]
276	GENIPQEKDIPDCPC	ubiquitination	[1]
286	PDCPCGAKRILEFQV	ubiquitination	[1]
302	PQLLNYLKADRLGKS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. 

Sequence Annotation

 ZN_FING 135 172 MYND-type.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 344 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; TAS:ProtInc. 

Interpro

 IPR007320; PDCD2_C.
 IPR002893; Znf_MYND. 

Pfam

 PF04194; PDCD2_C
 PF01753; zf-MYND 

SMART

  

PROSITE

 PS01360; ZF_MYND_1
 PS50865; ZF_MYND_2 

PRINTS