| Tag | Content |
|---|
| CPLM ID | CPLM-022732 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chloride channel protein 2 |
Protein Synonyms/Alias | ClC-2 |
Gene Name | Clcn2 |
Gene Synonyms/Alias | Clc2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 859 | SVTAQGVKVRPPLAS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. |
Sequence Annotation | DOMAIN 592 650 CBS 1.
DOMAIN 800 860 CBS 2.
MOTIF 169 173 Selectivity filter part_1 (By
MOTIF 211 215 Selectivity filter part_2 (By
MOTIF 465 469 Selectivity filter part_3 (By
BINDING 170 170 Chloride (By similarity).
BINDING 467 467 Chloride; via amide nitrogen (By
BINDING 561 561 Chloride (By similarity). |
Keyword | CBS domain; Chloride; Chloride channel; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 908 AA |
Protein Sequence | MAAATAAAAA AAAAGEGMEP RALQYEQTLM YGRYTQELGA FAKEEAARIR LGGPEPWKGS 60
PSARATPELL EYGQSRCARC RICSVRCHKF LVSRVGEDWI FLVLLGLLMA LVSWAMDYAI 120
AVCLQAQQWM SRGLNTNILL QYLAWVTYPV VLITFSAGFT QILAPQAVGS GIPEMKTILR 180
GVVLKEYLTL KTFVAKVIGL TCALGSGMPL GKEGPFVHIA SMCAALLSKF LSLFGGIYEH 240
ESRNTEMLAA ACAVGVGCCF AAPIGGVLFS IEVTSTFFAV RNYWRGFFAA TFSAFIFRVL 300
AVWNRDEETI TALFKTRFRL DFPFDLQELP AFAVIGIASG FGGALFVYLN RKIVQVMRKQ 360
KTINRFLMRK RLLFPALVTL LISTLTFPPG FGQFMAGQLS QKETLVTLFD NRTWVRQGLV 420
EDLELPSTSQ AWSPPRANVF LTLVIFILMK FWMSALATTI PVPCGAFMPV FVIGAAFGRL 480
VGESMAAWFP DGIHTDSSTY RIVPGGYAVV GAAALAGAVT HTVSTAVIVF ELTGQIAHIL 540
PVMIAVILAN AVAQSLQPSL YDSIIRIKKL PYLPELGWGR HQQYRVRVED IMVRDVPHVA 600
LSCTFRDLRL ALHRTKGRML ALVESPESMI LLGSIERSQV VALLGAQLSP ARRRQHMQKL 660
RKAQLSPPSD QESPPSSETS IRFQVNTEDS GFSGAHGQTH KPLKPALKRG PSNSTSLQEG 720
TTGNMESAGI ALRSLFCGSP PLEATSELEK SESCDKRKLK RVRISLASDS DPEAEMSPEE 780
ILEWEEQQLD EPVNFSDCKI DPAPFQLVER TSLHKTHTIF SLLGVDHAYV TSIGRLIGIV 840
TLKELRKAIE GSVTAQGVKV RPPLASFRDS ATSSSDTETT EVHALWGPRS RHGLPREGTP 900
SDSDDKCQ 908 |
Gene Ontology | GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW. GO:0005247; F:voltage-gated chloride channel activity; IMP:MGI. GO:0060689; P:cell differentiation involved in salivary gland development; IMP:MGI. GO:0060041; P:retina development in camera-type eye; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |