CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044513
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Neurofibromin truncated 
Protein Synonyms/Alias
  
Gene Name
 NF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58FDEQLPIKTGQQNTHubiquitination[1]
295DGFAESTKRKAAVWPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1656 AA 
Protein Sequence
SLPLPSPQPP LPALFPAQGA GPPFPPPPPG RGEDMAAHRP VEWVQAVVSR FDEQLPIKTG 60
QQNTHTKVST EHNKECLINI SKYKFSLVIS GLTTILKNVN NMRIFGEAAE KNLYLSQLII 120
LDTLEKCLAG QPKDTMRLDE TMLVKQLLPE ICHFLHTCRE GNQHAAELRN SASGVLFSLS 180
CNNFNAVFSR ISTRLQELTV CSEDNVDVHD IELLQYINVD CAKLKRLLKE TAFKFKALKK 240
VAQLAVINSL EKAFWNWVEN YPDEFTKLYQ IPQTDMAECA EKLFDLVDGF AESTKRKAAV 300
WPLQIILLIL CPEIIQDISK DVVDENNMNK KLFLDSLRKA LAGHGGSRQL TESAAIACVK 360
LCKASTYINW EDNSVIFLLV QSMVVDLKNL LFNPSKPFSR GSQPADVDLM IDCLVSCFRI 420
SPHNNQHFKI CLAQNSPSTF HYVLVNSLHR IITNSALDWW PKIDAVYCHS VELRNMFGET 480
LHKAVQGCGA HPAIRMAPSL TFKEKVTSLK FKEKPTDLET RSYKYLLLSM VKLIHADPKL 540
LLCNPRKQGP ETQGSTAELI TGLVQLVPQS HMPEIAQEAM EALLVLHQLD SIDLWNPDAP 600
VETFWEISSQ MLFYICKKLT SHQMLSSTEI LKWLREILIC RNKFLLKNKQ ADRSSCHFLL 660
FYGVGCDIPS SGNTSQMSMD HEELLRTPGA SLRKGKGNSS MDSAAGCSGT PPICRQAQTK 720
LEVALYMFLW NPDTEAVLVA MSCFRHLCEE ADIRCGVDEV SVHNLLPNYN TFMEFASVSN 780
MMSTGRAALQ KRVMALLRRI EHPTAGNTEA WEDTHAKWEQ ATKLILNYPK AKMEDGQAAE 840
SLHKTIVKRR MSHVSGGGSI DLSDTDSLQE WINMTGFLCA LGGVCLQQRS NSGLATYSPP 900
MGPVSERKGS MISVMSSEGN ADTPVSKFMD RLLSLMVCNH EKVGLQIRTN VKDLVGLELS 960
PALYPMLFNK LKNTISKFFD SQGQVLLTDT NTQFVEQTIA IMKNLLDNHT EGSSEHLGQA 1020
SIETMMLNLV RYVRVLGNMV HAIQIKTKLC QLVEVMMARR DDLSFCQEMK FRNKMVEYLT 1080
DWVMGTSNQA ADDDVKCLTR DLDQASMEAV VSLLAGLPLQ PEEGDGVELM EAKSQLFLKY 1140
FTLFMNLLND CSEVEDESAQ TGGRKRGMSR RLASLRHCTV LAMSNLLNAN VDSGLMHSIG 1200
LGYHKDLQTR ATFMEVLTKI LQQGTEFDTL AETVLADRFE RLVELVTMMG DQGELPIAMA 1260
LANVVPCSQW DELARVLVTL FDSRHLLYQL LWNMFSKEVE LADSMQTLFR GNSLASKIMT 1320
FCFKVYGATY LQKLLDPLLR IVITSSDWQH VSFEVDPTRL EPSESLEENQ RNLLQMTEKF 1380
FHAIISSSSE FPPQLRSVCH CLYQVVSQRF PQNSIGAVGS AMFLRFINPA IVSPYEAGIL 1440
DKKPPPRIER GLKLMSKILQ SIANHVLFTK EEHMRPFNDF VKSNFDAARR FFLDIASDCP 1500
TSDAVNHSLS FISDGNVLAL HRLLWNNQEK IGQYLSSNRD HKAVGRRPFD KMATLLAYLG 1560
PPEHKPVADT HWSSLNLTSS KFEEFMTRHQ VHEKEEFKAL KTLSIFYQAG TSKAGNPIFY 1620
YVARRIYYPN IVKGITKHLP RNSYPTLISG FSFPLL 1656 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR001936; RasGAP.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot. 
Pfam
 PF00616; RasGAP 
SMART
 SM00323; RasGAP 
PROSITE
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2 
PRINTS