CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033835
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NAD-dependent protein deacetylase sirtuin-3 
Protein Synonyms/Alias
  
Gene Name
 Sirt3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
57GGGSSEKKFSLQDVAacetylation[1]
57GGGSSEKKFSLQDVAsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MALDPLGAVV LQSIMALSGR LALAALRLWG PGGGRRPISL CVGASGGFGG GGSSEKKFSL 60
QDVAELLRTR ACSRVVVMVG AGISTPSGIP DFRSPGSGLY SNLQQYDIPY PEAIFELGFF 120
FHNPKPFFML AKELYPGHYR PNVTHYFLRL LHDKELLLRL YTQNIDGLER ASGIPASKLV 180
EAHGTFVTAT CTVCRRSFPG EDIWADVMAD RVPRCPVCTG VVKPDIVFFG EQLPARFLLH 240
MADFALADLL LILGTSLE 258 
Gene Ontology
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0070403; F:NAD+ binding; IEA:InterPro.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IDA:MGI. 
Interpro
 IPR003000; Sirtuin.
 IPR026591; Sirtuin_cat_small_dom.
 IPR026590; Ssirtuin_cat_dom. 
Pfam
 PF02146; SIR2 
SMART
  
PROSITE
 PS50305; SIRTUIN 
PRINTS