UniProt Accession

 G3UYY1_MOUSE; G3UYY1 

Genbank Protein ID

 AL596215 

Genbank Nucleotide ID

  

Protein Name

 Serine hydroxymethyltransferase 

Protein Synonyms/Alias

  

Gene Name

 Shmt1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	TLWASHEKMLSQPLK	acetylation	[1]
14	TLWASHEKMLSQPLK	succinylation	[1]
14	TLWASHEKMLSQPLK	ubiquitination	[2]
32	AEVYSIIKKESNRQR	ubiquitination	[2]
66	LGSCLNNKYSEGYPG	acetylation	[3]
66	LGSCLNNKYSEGYPG	ubiquitination	[2]
151	THGFMTDKKKISATS	ubiquitination	[2]
369	TDGGRAEKVLEACSI	ubiquitination	[2]
408	TLKEFKEKLAGDEKI	acetylation	[1]
414	EKLAGDEKIQSAVAT	acetylation	[1, 4]
414	EKLAGDEKIQSAVAT	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

 Interconversion of serine and glycine (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 441 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006544; P:glycine metabolic process; IEA:InterPro.
 GO:0006563; P:L-serine metabolic process; IEA:InterPro.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 

Interpro

 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 

Pfam

 PF00464; SHMT 

SMART

  

PROSITE

 PS00096; SHMT 

PRINTS