Tag | Content |
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CPLM ID | CPLM-014233 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adseverin |
Protein Synonyms/Alias | Gelsolin-like protein; Scinderin |
Gene Name | Scin |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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319 | TAEEFLQKMKYSTNT | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity). Isoform 2 fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca(2+)-dependent manner. |
Sequence Annotation | REPEAT 27 76 Gelsolin-like 1. REPEAT 148 188 Gelsolin-like 2. REPEAT 265 307 Gelsolin-like 3. REPEAT 398 451 Gelsolin-like 4. REPEAT 523 564 Gelsolin-like 5. REPEAT 626 668 Gelsolin-like 6. REGION 1 363 Actin-severing (Potential). REGION 112 119 Polyphosphoinositide binding (By REGION 138 146 Polyphosphoinositide binding (By REGION 364 715 Ca(2+)-dependent actin binding. MOD_RES 102 102 Phosphotyrosine. MOD_RES 599 599 Phosphotyrosine. |
Keyword | Actin capping; Actin-binding; Alternative splicing; Calcium; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 715 AA |
Protein Sequence | MAQELQHPEF ARAGQQAGLQ VWRVEKLELV PVPQGAYGDF YVGDAYLVLH TTKSSRGFSY 60 RLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQSRELQ GYESTDFVGY FKGGLKYKAG 120 GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWESF NKGDCFIIDL GTEIYQWCGS 180 SCNKYERLKA SQVAIGIRDN ERKGRSQLIV VEEGSEPSEL MKVLGRKPEL PDGDNDDDVV 240 ADISNRKMAK LYMVSDASGS MKVTLVAEEN PFSMGMLLSE ECFILDHGAA KQIFVWKGKN 300 ANPQERKTAM KTAEEFLQKM KYSTNTQIQV LPEGGETPIF KQFFKDWKDK DQSDGFGKVY 360 ITEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGGVEI WRVENSGRVQ IDPSSYGEFY 420 GGDCYIILYT YPRGQIIYTW QGANATRDEL TMSAFLTVQL DRSLGGQAVQ VRVSQGKEPA 480 HLLSLFKDKP LIIYKNGTSK KEGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDT 540 FVLKLPRNNG FIWIGKGASQ EEEKGAEYVA DVLKCKASRI QEGKEPEEFW NSLGGRGDYQ 600 TSPLLETRAE DHPPRLYGCS NKTGRFIIEE VPGEFTQDDL AEDDVMLLDA WEQIFIWIGK 660 DANEVEKKES VKSAKMYLET DPSGRDKRTP IVIIKQGHEP PTFTGWFLGW DSSRW 715 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. GO:0051014; P:actin filament severing; IEA:Compara. GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. GO:0043065; P:positive regulation of apoptotic process; IEA:Compara. GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Compara. GO:0032330; P:regulation of chondrocyte differentiation; ISS:UniProtKB. |
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