UniProt Accession

 IGHA2_HUMAN; P01877 

Genbank Protein ID

 J00221; AL928742 

Genbank Nucleotide ID

 AAB59396.1 

Protein Name

 Ig alpha-2 chain C region 

Protein Synonyms/Alias

  

Gene Name

 IGHA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
155	TWTPSSGKSAVQGPP	ubiquitination	[1]
245	LARGFSPKDVLVRWL	ubiquitination	[1]
262	SQELPREKYLTWASR	ubiquitination	[1]
293	RVAAEDWKKGDTFSC	ubiquitination	[1]
294	VAAEDWKKGDTFSCM	ubiquitination	[1]
314	LPLAFTQKTIDRMAG	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. 

Sequence Annotation

 DOMAIN 6 98 Ig-like 1.
 DOMAIN 112 207 Ig-like 2.
 DOMAIN 215 317 Ig-like 3.
 CARBOHYD 47 47 N-linked (GlcNAc...).
 CARBOHYD 92 92 N-linked (GlcNAc...).
 CARBOHYD 131 131 N-linked (GlcNAc...).
 CARBOHYD 205 205 N-linked (GlcNAc...).
 CARBOHYD 327 327 N-linked (GlcNAc...).
 DISULFID 26 85 Probable.
 DISULFID 101 101 Interchain (with light chain) (Probable).
 DISULFID 109 109 Interchain (with heavy chain) (Probable).
 DISULFID 110 167 Probable.
 DISULFID 134 191 Probable.
 DISULFID 169 169 Interchain (with heavy chain) (Probable).
 DISULFID 179 179 Interchain (with heavy chain of another
 DISULFID 237 300 Probable.
 DISULFID 339 339 Interchain (with J chain) (Probable).  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin C region; Immunoglobulin domain; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0016020; C:membrane; NAS:UniProtKB.
 GO:0003823; F:antigen binding; TAS:UniProtKB.
 GO:0006955; P:immune response; NAS:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS