CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039047
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein kinase C beta type 
Protein Synonyms/Alias
  
Gene Name
 Prkcb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
129GLSDPYVKLKLIPDPacetylation[1]
137LKLIPDPKSESKQKTacetylation[1]
252GTKAPEEKTANTISKubiquitination[2]
294KVMLSERKGTDELYAubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 603 AA 
Protein Sequence
VCCFVVHKRC HEFVTFSCPG ADKGPASDDP RSKHKFKIHT YSSPTFCDHC GSLLYGLIHQ 60
GMKCDTCMMN VHKRCVMNVP SLCGTDHTER RGRIYIQAHI DREVLIVVVR DAKNLVPMDP 120
NGLSDPYVKL KLIPDPKSES KQKTKTIKCS LNPEWNETFR FQLKESDKDR RLSVEIWDWD 180
LTSRNDFMGS LSFGISELQK AGVDGWFKLL SQEEGEYFNV PVPPEGSEGN EELRQKFERA 240
KIGQGTKAPE EKTANTISKF DNNGNRDRMK LTDFNFLMVL GKGSFGKVML SERKGTDELY 300
AVKILKKDVV IQDDDVECTM VEKRVLALPG KPPFLTQLHS CFQTMDRLYF VMEYVNGGDL 360
MYHIQQVGRF KEPHAVFYAA EIAIGLFFLQ SKGIIYRDLK LDNVMLDSEG HIKIADFGMC 420
KENIWDGVTT KTFCGTPDYI APEIIAYQPY GKSVDWWAFG VLLYEMLAGQ APFEGEDEDE 480
LFQSIMEHNV AYPKSMSKEA VAICKGLMTK HPGKRLGCGP EGERDIKEHA FFRYIDWEKL 540
ERKEIQPPYK PKARDKRDTS NFDKEFTRQP VELTPTDKLF IMNLDQNEFA GFSYTNPEFV 600
INV 603 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004697; F:protein kinase C activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR020454; DAG/PE-bd.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR014375; Protein_kinase_C_a/b/g.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00130; C1_1
 PF00168; C2
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00109; C1
 SM00239; C2
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50004; C2
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00360; C2DOMAIN.
 PR00008; DAGPEDOMAIN.