| Tag | Content |
|---|
| CPLM ID | CPLM-014261 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium-dependent phosphate transport protein 2A |
Protein Synonyms/Alias | Sodium-phosphate transport protein 2A; Na(+)-dependent phosphate cotransporter 2A; NaPi-7; Sodium/phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; NaPi-2a; Solute carrier family 34 member 1 |
Gene Name | Slc34a1 |
Gene Synonyms/Alias | Npt2; Slc17a2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 85 | LAQEEEQKPEPRLSQ | ubiquitination | [1] | | 93 | PEPRLSQKLAQVGTK | ubiquitination | [1] | | 268 | RDAPDLLKVITEPFT | ubiquitination | [1] | | 569 | RSPGHLPKWLQTWDF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. |
Sequence Annotation | MOD_RES 506 506 Phosphothreonine; by PKC (Potential).
CARBOHYD 298 298 N-linked (GlcNAc...) (Potential).
CARBOHYD 328 328 N-linked (GlcNAc...) (Potential).
DISULFID 225 520 By similarity.
DISULFID 306 334 By similarity. |
Keyword | Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 637 AA |
Protein Sequence | MMSYSERLGG PAVSPLPVRG RHMVHGATFA YVPSPQVLHR IPGTSTYAIS SLSPVTLTEH 60
SCPCGEVLEC HDPLPTKLAQ EEEQKPEPRL SQKLAQVGTK LLKVPLMLAF LYLFVCSLDV 120
LSSAFQLAGG KVAGDIFKDN AILSNPVAGL VVGILVTVLV QSSSTSTSII VSMVSSGLLE 180
VSSAIPIIMG SNIGTSVTNT IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA 240
TGYLHHVTGL VVASFNIRGG RDAPDLLKVI TEPFTRLIIQ LDKSVITSIA VGDESLRNHS 300
LIRIWCHPDT TEASTSMSRV EAIGSLANTT MEKCNHIFVD TGLPDLAVGL ILLAGSLVVL 360
CTCLILLVKM LNSLLKGQVM SSRRSSTQTD FPAPFTWVTG YFAMVVGASM TFVVQSSSVF 420
TSAITPLIGL GVISIERAYP LTLGSNIGTT TTAILAALAS PREKLSSSFQ IALCHFFFNI 480
SGILLWYPLP CTRLPIRMAK ALGKRTAKYR WFAVLYLLVC FLLLPSLVFG ISMAGWQAMV 540
GVGTPFGALL AFVVLVNVLQ SRSPGHLPKW LQTWDFLPRW MHSLQPLDGL ITRATLCYAR 600
PEPRSPQLPP RVFLEELPPA TPSPRLALPA HHNATRL 637 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; IEA:InterPro. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0046849; P:bone remodeling; IMP:MGI. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |