UniProt Accession

 BLVRB_HUMAN; P30043; A6NKD8; B2R5C6; P32078; P53005; Q32LZ2 

Genbank Protein ID

 D26308; D32143; AK312137; AY340485; AC010271; CH471126; BC109371 

Genbank Nucleotide ID

 BAA05370.1; BAA06874.1; BAG35073.1; AAP88933.1; EAW56969.1; AAI09372.1 

Protein Name

 Flavin reductase (NADPH) 

Protein Synonyms/Alias

 FR; Biliverdin reductase B; BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR 

Gene Name

 BLVRB 

Gene Synonyms/Alias

 FLR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
178	GPSRVISKHDLGHFM	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. 

Sequence Annotation

 NP_BIND 10 15 NADP.
 NP_BIND 54 55 NADP.
 NP_BIND 75 78 NADP.
 BINDING 35 35 NADP.
 BINDING 132 132 NADP.
 BINDING 153 153 Substrate.
 BINDING 154 154 NADP; via amide nitrogen.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0004074; F:biliverdin reductase activity; IDA:UniProtKB.
 GO:0042602; F:riboflavin reductase (NADPH) activity; IDA:UniProtKB.
 GO:0042167; P:heme catabolic process; IDA:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS