| Tag | Content |
|---|
| CPLM ID | CPLM-023162 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cell cycle progression protein 1 |
Protein Synonyms/Alias | Cell cycle progression restoration protein 8 |
Gene Name | CCPG1 |
Gene Synonyms/Alias | CCP8; CPR8; KIAA1254 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 156 | KMSFETQKTNLATEN | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation. |
Sequence Annotation | REGION 1 308 Interaction with MCF2L and SRC (By |
Keyword | Alternative splicing; Cell cycle; Coiled coil; Complete proteome; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 757 AA |
Protein Sequence | MSTFFLIVFS SQPSDDESSS DETSNQPSPA FRRRRARKKT VSASESEDRL VAEQETEPSK 60
ELSKRQFSSG LNKCVILALV IAISMGFGHF YGTIQIQKRQ QLVRKIHEDE LNDMKDYLSQ 120
CQQEQESFID YKSLKENLAR CWTLTEAEKM SFETQKTNLA TENQYLRVSL EKEEKALSSL 180
QEELNKLREQ IRILEDKGTS TELVKENQKL KQHLEEEKQK KHSFLSQRET LLTEAKMLKR 240
ELERERLVTT ALRGELQQLS GSQLHGKSDS PNVYTEKKEI AILRERLTEL ERKLTFEQQR 300
SDLWERLYVE AKDQNGKQGT DGKKKGGRGS HRAKNKSKET FLGSVKETFD AMKNSTKEFV 360
RHHKEKIKQA KEAVKENLKK FSDSVKSTFR HFKDTTKNIF DEKGNKRFGA TKEAAEKPRT 420
VFSDYLHPQY KAPTENHHNR GPTMQNDGRK EKPVHFKEFR KNTNSKKCSP GHDCRENSHS 480
FRKACSGVFD CAQQESMSLF NTVVNPIRMD EFRQIIQRYM LKELDTFCHW NELDQFINKF 540
FLNGVFIHDQ KLFTDFVNDV KDYLRNMKEY EVDNDGVFEK LDEYIYRHFF GHTFSPPYGP 600
RSVYIKPCHY SSL 613 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:2001106; P:regulation of Rho guanyl-nucleotide exchange factor activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |