UniProt Accession

 TEHB_ECOLI; P25397; P76866 

Genbank Protein ID

 M74072; U00096; AP009048 

Genbank Nucleotide ID

 AAA19564.1; AAC74512.1; BAA15059.1 

Protein Name

 Tellurite methyltransferase 

Protein Synonyms/Alias

 Chalcogen-detoxifying protein TehB; Selenite methyltransferase; Tellurite resistance protein TehB 

Gene Name

 tehB 

Gene Synonyms/Alias

 b1430; JW1426 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
12	DENYFTDKYELTRTH	acetylation	[1]
27	SEVLEAVKVVKPGKT	acetylation	[1]
60	YDVDAWDKNAMSIAN	acetylation	[1]
72	IANVERIKSIENLDN	acetylation	[1]
167	YEGWERVKYNEDVGE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds. 

Sequence Annotation

 REGION 86 87 S-adenosyl-L-methionine.
 BINDING 38 38 S-adenosyl-L-methionine; via carbonyl
 BINDING 43 43 S-adenosyl-L-methionine.
 BINDING 59 59 S-adenosyl-L-methionine.
 BINDING 102 102 S-adenosyl-L-methionine.
 BINDING 177 177 Substrate (Probable).  

Keyword

 3D-structure; Antibiotic resistance; Complete proteome; Cytoplasm; Detoxification; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Tellurium resistance; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IDA:EcoCyc.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0046690; P:response to tellurium ion; IMP:EcoCyc. 

Interpro

 IPR015985; TehB-like_dom.
 IPR004537; Tellurite-R_MeTrfase_TehB. 

Pfam

 PF03848; TehB 

SMART

  

PROSITE

  

PRINTS