| Tag | Content |
|---|
| CPLM ID | CPLM-015206 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tryptophan--tRNA ligase, cytoplasmic |
Protein Synonyms/Alias | Tryptophanyl-tRNA synthetase; TrpRS; T1-TrpRS; T2-TrpRS |
Gene Name | Wars |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 454 | AEHQARRKAVTEETV | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2- TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). |
Sequence Annotation | DOMAIN 12 68 WHEP-TRS.
MOTIF 168 177 "HIGH" region.
MOTIF 353 357 "KMSKS" region. |
Keyword | Aminoacyl-tRNA synthetase; Angiogenesis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 481 AA |
Protein Sequence | MADMPSGESC TSPLELFNSI AAQGELVRSL KAGNAPKDEI ESAVKMLLSL KMNYKTAMGE 60
EYKAGCPPGN STAGSNGDPD ATKASEDFVD PWTVRTSSAK GIDYDKLIVQ FGSSKIDKEL 120
INRIERATGQ RPHRFLRRGI FFSHRDMNQI LDAYENKKPF YLYTGRGPSS EAMHLGHLVP 180
FIFTKWLQDV FDVPLVIQMS DDEKYLWKDL TLEQAYSYTV ENAKDIIACG FDVNKTFIFS 240
DLEYMGQSPG FYKNVVKIQK HVTFNQVKGI FGFTDSDCIG KISFPAVQAA PSFSNSFPKI 300
FRDRTDIQCL IPCAIDQDPY FRMTRDVAPR IGHPKPALLH STFFPALQGA QTKMSASDPN 360
SSIFLTDTAK QIKSKVNKHA FSGGRDTVEE HRQFGGNCEV DVSFMYLTFF LEDDDSLEQI 420
RKDYTSGAML TGELKKTLID VLQPLIAEHQ ARRKAVTEET VKEFMAPRQL SFHFQCFCFD 480
T 481 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004830; F:tryptophan-tRNA ligase activity; IEA:EC. GO:0001525; P:angiogenesis; IEA:UniProtKB-KW. GO:0045765; P:regulation of angiogenesis; IEA:Compara. GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |