CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032600
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine--tRNA ligase 
Protein Synonyms/Alias
 Lysyl-tRNA synthetase 
Gene Name
 TGGT1_063200, TGVEG_043580 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
74VATEAPEKRQANVNGacetylation[1]
138DPTQYFEKRCHLVQDacetylation[1, 2]
Reference
 [1] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842]
 [2] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 658 AA 
Protein Sequence
MRSPCSGGKS LFEALSLVFC WRPRVWPRVL QSGASQSRHQ FLNSYRLPGT SPHFRPVSTM 60
APPAGDVATE APEKRQANVN GDEPKISASE RRRLRKAEQA AAKKDSKQQQ QEGNSSPAVN 120
NKAQKPEEEL DPTQYFEKRC HLVQDLQRKG VPAYPHKFQV TLTIPEFIKM YGGLGDGEHL 180
ENEEVQIAGR ISRVSASGQK LRFYDIRGDG EKIQVMSNFS YHDEKAGDFS EVHNRFRRGD 240
VIGIRGFPGK SKRGELSIFP REVTLLSPCL HMLPERNSLK DFEVRFRHRY LDLMVNDETR 300
KTFLIRSRIV NYLRRFLEDR GFVEVETPMM NVIAGGAAAR PFKTHHNDLD MDLYMRIAPE 360
LFLKMLIVGG MDRVFEIGKN FRNEGIDMTH NPEFTACEFY WAYADYNDLM NFTEELVSSM 420
VMALHGTYQI QFHPDGPGSE PVTLDFTPPF ARLSMVEEIE KQAGVTLPRP LDGDECIAFM 480
KELLIKNKVD LPQPATSAKL LDALCGEYVE CQARTKPVFI TEHPQIMSPL AKWHRSKPEL 540
TERFELFLMG KELCNAYTEL NDPVRQRECF MDQAKAKAAG DDEATCIDEV FCTALEYGLP 600
PTGGWGIGID RLTMFLSDHN TIKEVILFPA MRPQPLVGIP GKHGSDAGAP GEASAPAQ 658 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004824; F:lysine-tRNA ligase activity; IEA:EC.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006430; P:lysyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR004364; aa-tRNA-synt_II.
 IPR018150; aa-tRNA-synt_II-like.
 IPR006195; aa-tRNA-synth_II.
 IPR002313; Lys-tRNA-ligase_II.
 IPR018149; Lys-tRNA-synth_II_C.
 IPR012340; NA-bd_OB-fold.
 IPR004365; NA-bd_OB_tRNA-helicase. 
Pfam
 PF00152; tRNA-synt_2
 PF01336; tRNA_anti 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR00982; TRNASYNTHLYS.