UniProt Accession

 NFE4_HUMAN; Q86UQ8 

Genbank Protein ID

 AY258907 

Genbank Nucleotide ID

 AAP13531.1 

Protein Name

 Transcription factor NF-E4 

Protein Synonyms/Alias

  

Gene Name

 NFE4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
43	DLPLRPRKQATAAGQ	acetylation	[1]

Reference

 [1] Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
 Zhao Q, Cumming H, Cerruti L, Cunningham JM, Jane SM.
 J Biol Chem. 2004 Oct 1;279(40):41477-86. [PMID: 15273251] 

Functional Description

 Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. 

Sequence Annotation

 MOD_RES 43 43 N6-acetyllysine.  

Keyword

 Acetylation; Activator; Alternative initiation; Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

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