CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018423
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Threonine--tRNA ligase 
Protein Synonyms/Alias
 Threonyl-tRNA synthetase; ThrRS 
Gene Name
 thrS 
Gene Synonyms/Alias
 STM1333 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
136EKNYDVIKKKVSWHDacetylation[1]
137KNYDVIKKKVSWHDAacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 REGION 243 534 Catalytic.
 METAL 334 334 Zinc; catalytic (By similarity).
 METAL 385 385 Zinc; catalytic (By similarity).
 METAL 511 511 Zinc; catalytic (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 642 AA 
Protein Sequence
MPVITLPDGS QRHYDHPVSP MDVALDIGPG LAKATIAGRV NGELVDASDL IENDATLSII 60
TAKDEEGLEI IRHSCAHLLG HAIKQLWPHT KMAIGPVVDN GFYYDVDLDR TLTQEDVEAL 120
EKRMHELAEK NYDVIKKKVS WHDARETFVK RGETYKVAIL DENIAHDDKP GLYHHEEYVD 180
MCRGPHVPNM RFCHHFKLMK TAGAYWRGDS NNKMLQRIYG TAWADKKALN AYLQRLEEAA 240
KRDHRKIGKQ LDLYHMQEEA PGMVFWHNDG WTIFRELEVF VRSKLKEYQY QEVKGPFMMD 300
RVLWEKTGHW DNYKDAMFTT SSENREYCIK PMNCPGHVQI FNQGLKSYRD LPLRMAEFGS 360
CHRNEPSGAL HGLMRVRGFT QDDAHIFCTE EQIRDEVNAC IRMVYDMYST FGFEKIVVKL 420
STRPDKRIGS DEMWDRAEAD LAVALEENNI PFEYQLGEGA FYGPKIEFTL YDCLDRAWQC 480
GTVQLDFSLP SRLSASYVGE DNERKVPVMI HRAILGSMER FIGILTEEFA GFFPTWLAPV 540
QVVVMNITDS QSEYVNELTQ KLQNAGIRVK ADLRNEKIGF KIREHTLRRV PYMLVCGDKE 600
VEAGKVAVRT RRGKDLGSLD VNDVIEKLQQ EIRSRSLQQL EE 642 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004829; F:threonine-tRNA ligase activity; IEA:HAMAP.
 GO:0006435; P:threonyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR012675; Beta-grasp_dom.
 IPR004095; TGS.
 IPR012676; TGS-like.
 IPR002320; Thr-tRNA-ligase_IIa.
 IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
 IPR012947; tRNA_SAD. 
Pfam
 PF03129; HGTP_anticodon
 PF02824; TGS
 PF00587; tRNA-synt_2b
 PF07973; tRNA_SAD 
SMART
 SM00863; tRNA_SAD 
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR01047; TRNASYNTHTHR.