CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038886
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Ank3 
Protein Synonyms/Alias
  
Gene Name
 Ank3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
285TPLHVASKRGNANMVacetylation[1]
1037CRLVKRHKLANPPPMubiquitination[2]
1097SENGETWKEHQFDSKacetylation[1]
1181FPEGALTKRIRVGLQacetylation[1]
1408NRLPFSIKVRDTSQEacetylation[1]
1427LSFLKEPKTTKGLPQacetylation[1]
2380SQSFMLLKKWVTRDGacetylation[1]
2569PCVPVGMKKMTRTPAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2598 AA 
Protein Sequence
MAHAASQLKK NRDLEINAEE ETEKKKKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY 60
IKNGVDVNIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA 120
EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVRFLL DNGASQSLAT EDGFTPLAVA 180
LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDTNADI ESKLSIGRAR 240
KSGFTPLHIA AHYGNINVAT LLLNRAAAVD FTARNDITPL HVASKRGNAN MVKLLLDRGA 300
KIDAKTRDGL TPLHCGARSG HEQVVEMLLD RAAPILSKTK NGLSPLHMAT QGDHLNCVQL 360
LLQHNVPVDD VTNDYLTALH VAAHCGHYKV AKVLLDKKAN PNAKALNGFT PLHIACKKNR 420
IRVMELLLKH GASIQAVTES GLTPIHVAAF MGHVNIVSQL MHHGASPNTT NVRGETALHM 480
AARSGQAEVV RYLVQDGAQV EAKAKDDQTP LHISARLGKA DIVQQLLQQG ASPNAATTSG 540
YTPLHLSARE GHEDVAAFLL DHGASLSITT KKGFTPLHVA AKYGKLEVAS LLLQKSASPD 600
AAGKSGLTPL HVAAHYDNQK VALLLLDQGA SPHAAAKNGY TPLHIAAKKN QMDIATSLLE 660
YGADANAVTR QGIASVHLAA QEGHVDMVSL LLSRNANVNL SNKSGLTPLH LAAQEDRVNV 720
AEVLVNQGAH VDAQTKMGYT PLHVGCHYGN IKIVNFLLQH SAKVNAKTKN GYTPLHQAAQ 780
QGHTHIINVL LQNNASPNEL TVNGNTALAI ARRLGYISVV DTLKVVTEEI MTTTTITEKH 840
KMNVPETMNE VLDMSDDEVG KASAPEKLSD GEYISDGEEG EDAITGDTDK YLGPQDLKEL 900
GDDSLPAEGY VGFSLGARSA SLRSFSSDRS YTLNRSSYAR DSMMIEELLV PSKEQHLPFT 960
REFDSDSLRH YSWAADTLDN VNLVSSPVHS GFLVSFMVDA RGGSMRGSRH HGMRIIIPPR 1020
KCTAPTRITC RLVKRHKLAN PPPMVEGEGL ASRLVEMGPA GAQFLGPVIV EIPHFGSMRG 1080
KERELIVLRS ENGETWKEHQ FDSKNEDLSE LLNGMDEELD SPEELGTKRI CRIITKDFPQ 1140
YFAVVSRIKQ ESNQIGPEGG ILSSTTVPLV QASFPEGALT KRIRVGLQAQ PVPEETVKKI 1200
LGNKATFSPI VTVEPRRRKF HKPITMTIPV PPPSGEGVSN GYKGDTTPSL RLLCSITGGT 1260
SPAQWEDITG TTPLTFIKDC VSFTTNVSAR FWLADCHQVL ETVGLASQLY RELICVPYMA 1320
KFVVFAKTND PVESSLRCFC MTDDRVDKTL EQQENFEEVA RSKDIEVLEG KPIYVDCYGN 1380
LAPLTKGGQQ LVFNFYSFKE NRLPFSIKVR DTSQEPCGRL SFLKEPKTTK GLPQTAVCNL 1440
NITLPAHKKA EKADRRQSFT SLALRKRYSY LTEPSMKTVE RSSGTARSLP TTYSHKPFFS 1500
TRPYQSWTTT PLTVPGPAKS GSLSSSPSNT PSASPLKSIW SVSTPSPIKS TLGASTTSSV 1560
KSISDVASPI RSFRTISSPI RTSVSTPSPI KSTLGASTTS SVKSISDVAP IKGLAPNSTL 1620
SSRTSPVTTA GSLLERSSIT MTPPASPKAN ITMYSSSLPF KSIITSAAPL ISSPLKSVVS 1680
PTKSAAKAAM ASTLSSPLKQ MSGHAEVALV NGSVSPLKYP SSSALINGCK ATATLQDKIS 1740
TATNAVSSVV SAAPDTVEKA LSTTTAMPFS PLRSYVSAAA PSAFQSLRAP SASALYTSLG 1800
PSVAVTTSSV TSSIITVPVY SVVNVLPEPA LKKLPDSNSL TKSAAALLSP IKTLTTETRP 1860
QPHFNRTSSP VKSSLFLASS ALKPSVPSSL SSSQEILKDV AEMKEDLMRM TAILQTDVPE 1920
EKPFQTDLPR EGRIDDEEPF KIVEKVKEDL VKVSEILKKD VCVESKGPPK SPKSDKGHSP 1980
EDDWTEFSSE EIREARQAAA SHAPSLPERV HGKANLTRVI DYLTNDIGSS SLTNLKYKFE 2040
EAKKEGEERQ KRILKPAMAL QEHKLKMPPA SMRPSTSEKE LCKMADSFFG TDAILESPDD 2100
FSQHDQDKSP LSDSGFETRS EKTPSAPQSA ESTGPKPLFH EVPIPPVITE TRTEVVHVIR 2160
SYEPSTGEIP QSQPEDPVSP KPPPTFMELE PKPTAPSIKE KVKAFQMKAS SEEEDHSRVL 2220
SKGMRVKEET HITTTTRMVY HSPPGSECAS ERIEETMSVH DIMKAFQSGR DPSKELAGLF 2280
EHKSAMSPDV AKSAAETSAQ HAEKDNQMKP KLERIIEVHI EKGPQSPCER TDIRMAIVAD 2340
HLGLSWTELA RELNFSVDEI NQIRVENPNS LISQSFMLLK KWVTRDGKNA TTDALTSVLT 2400
KINRIDIVTL LEGPIFDYGN ISGTRSFADE NNVFHDPVDG WQNETPSGSL ESPAQARRIT 2460
GGLLDRLDDS SDQVRDPITS YLTGEAGKFE ANGNHAEVIP EAKAKAYFPE SQNDIGKQSI 2520
KENLKPKTHG CGRAEEPVSP LTAYQKSLEE TSKLVIEDAP KPCVPVGMKK MTRTPADGKA 2580
RLNLQEEEGS ARSEPKQG 2598 
Gene Ontology
 GO:0043194; C:axon initial segment; IDA:RGD.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0014704; C:intercalated disc; IDA:RGD.
 GO:0031594; C:neuromuscular junction; IDA:RGD.
 GO:0033268; C:node of Ranvier; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0045211; C:postsynaptic membrane; IDA:RGD.
 GO:0016529; C:sarcoplasmic reticulum; IDA:RGD.
 GO:0030018; C:Z disc; IDA:RGD.
 GO:0007528; P:neuromuscular junction development; IEP:RGD.
 GO:0010650; P:positive regulation of cell communication by electrical coupling; IMP:RGD.
 GO:0034112; P:positive regulation of homotypic cell-cell adhesion; IMP:RGD.
 GO:0090314; P:positive regulation of protein targeting to membrane; IMP:RGD.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR000906; ZU5. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF00531; Death
 PF00791; ZU5 
SMART
 SM00248; ANK
 SM00005; DEATH
 SM00218; ZU5 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50017; DEATH_DOMAIN
 PS51145; ZU5 
PRINTS
 PR01415; ANKYRIN.