CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002071
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hyaluronan and proteoglycan link protein 1 
Protein Synonyms/Alias
 Cartilage-linking protein 1; Cartilage-link protein; Proteoglycan link protein 
Gene Name
 Hapln1 
Gene Synonyms/Alias
 Crtl1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
243RNYGFWDKDKSRYDVacetylation[1]
340RFVGFPDKKHKLYGVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. 
Sequence Annotation
 DOMAIN 38 152 Ig-like V-type.
 DOMAIN 159 254 Link 1.
 DOMAIN 259 351 Link 2.
 CARBOHYD 56 56 N-linked (GlcNAc...).
 DISULFID 61 139
 DISULFID 181 252
 DISULFID 205 226
 DISULFID 279 349
 DISULFID 304 325  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Extracellular matrix; Glycoprotein; Hyaluronic acid; Immunoglobulin domain; Reference proteome; Repeat; Secreted. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MRSLLFLVLI SVCRADHLSD SYTPDQDRVI HIQAENGPRL LVEAEQAKVF SHRGGNVTLP 60
CKFYRDPTAF GSGIHKIRIK WTKLTSDYLR EVDVFVSMGY HKKTYGGYQG RVFLKGGSDN 120
DASLIITDLT LEDYGRYKCE VIEGLEDDTA VVALELQGVV FPYFPRLGRY NLNFHEARQA 180
CLDQDAVIAS FDQLYDAWRG GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF 240
WDKDKSRYDV FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKLLG 300
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF RAYN 354 
Gene Ontology
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0005540; F:hyaluronic acid binding; TAS:RGD.
 GO:0005198; F:structural molecule activity; TAS:RGD.
 GO:0007155; P:cell adhesion; IEA:InterPro. 
Interpro
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr.
 IPR000538; Link. 
Pfam
 PF07686; V-set
 PF00193; Xlink 
SMART
 SM00406; IGv
 SM00445; LINK 
PROSITE
 PS50835; IG_LIKE
 PS01241; LINK_1
 PS50963; LINK_2 
PRINTS
 PR01265; LINKMODULE.