CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021632
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleotide-binding oligomerization domain-containing protein 2 
Protein Synonyms/Alias
 Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1 
Gene Name
 NOD2 
Gene Synonyms/Alias
 CARD15; IBD1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
655CIQASEGKDSSVAALubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). 
Sequence Annotation
 DOMAIN 26 122 CARD 1.
 DOMAIN 126 218 CARD 2.
 DOMAIN 293 618 NACHT.
 REPEAT 791 812 LRR 1.
 REPEAT 816 839 LRR 2.
 REPEAT 844 865 LRR 3.
 REPEAT 872 884 LRR 4.
 REPEAT 900 920 LRR 5.
 REPEAT 928 949 LRR 6.
 REPEAT 956 976 LRR 7.
 REPEAT 984 1005 LRR 8.
 REPEAT 1012 1032 LRR 9.
 NP_BIND 299 306 ATP (Potential).
 MOTIF 63 77 ATG16L1-binding motif.  
Keyword
 Alternative initiation; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; Leucine-rich repeat; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1040 AA 
Protein Sequence
MGEEGGSASH DEEERASVLL GHSPGCEMCS QEAFQAQRSQ LVELLVSGSL EGFESVLDWL 60
LSWEVLSWED YEGFHLLGQP LSHLARRLLD TVWNKGTWAC QKLIAAAQEA QADSQSPKLH 120
GCWDPHSLHP ARDLQSHRPA IVRRLHSHVE NMLDLAWERG FVSQYECDEI RLPIFTPSQR 180
ARRLLDLATV KANGLAAFLL QHVQELPVPL ALPLEAATCK KYMAKLRTTV SAQSRFLSTY 240
DGAETLCLED IYTENVLEVW ADVGMAGPPQ KSPATLGLEE LFSTPGHLND DADTVLVVGE 300
AGSGKSTLLQ RLHLLWAAGQ DFQEFLFVFP FSCRQLQCMA KPLSVRTLLF EHCCWPDVGQ 360
EDIFQLLLDH PDRVLLTFDG FDEFKFRFTD RERHCSPTDP TSVQTLLFNL LQGNLLKNAR 420
KVVTSRPAAV SAFLRKYIRT EFNLKGFSEQ GIELYLRKRH HEPGVADRLI RLLQETSALH 480
GLCHLPVFSW MVSKCHQELL LQEGGSPKTT TDMYLLILQH FLLHATPPDS ASQGLGPSLL 540
RGRLPTLLHL GRLALWGLGM CCYVFSAQQL QAAQVSPDDI SLGFLVRAKG VVPGSTAPLE 600
FLHITFQCFF AAFYLALSAD VPPALLRHLF NCGRPGNSPM ARLLPTMCIQ ASEGKDSSVA 660
ALLQKAEPHN LQITAAFLAG LLSREHWGLL AECQTSEKAL LRRQACARWC LARSLRKHFH 720
SIPPAAPGEA KSVHAMPGFI WLIRSLYEMQ EERLARKAAR GLNVGHLKLT FCSVGPTECA 780
ALAFVLQHLR RPVALQLDYN SVGDIGVEQL LPCLGVCKAL YLRDNNISDR GICKLIECAL 840
HCEQLQKLAL FNNKLTDGCA HSMAKLLACR QNFLALRLGN NYITAAGAQV LAEGLRGNTS 900
LQFLGFWGNR VGDEGAQALA EALGDHQSLR WLSLVGNNIG SVGAQALALM LAKNVMLEEL 960
CLEENHLQDE GVCSLAEGLK KNSSLKILKL SNNCITYLGA EALLQALERN DTILEVWLRG 1020
NTFSLEEVDK LGCRDTRLLL 1040 
Gene Ontology
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:HGNC.
 GO:0005886; C:plasma membrane; IDA:HGNC.
 GO:0031982; C:vesicle; IDA:HGNC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0032500; F:muramyl dipeptide binding; IDA:HGNC.
 GO:0042834; F:peptidoglycan binding; IDA:HGNC.
 GO:0035419; P:activation of MAPK activity involved in innate immune response; ISS:BHF-UCL.
 GO:0071224; P:cellular response to peptidoglycan; IEA:Compara.
 GO:0002367; P:cytokine production involved in immune response; IMP:UniProtKB.
 GO:0042742; P:defense response to bacterium; IDA:HGNC.
 GO:0050830; P:defense response to Gram-positive bacterium; IEA:Compara.
 GO:0016045; P:detection of bacterium; IDA:HGNC.
 GO:0032498; P:detection of muramyl dipeptide; IDA:HGNC.
 GO:0002381; P:immunoglobulin production involved in immunoglobulin mediated immune response; IEA:Compara.
 GO:0045087; P:innate immune response; NAS:UniProtKB.
 GO:0002227; P:innate immune response in mucosa; IEA:Compara.
 GO:0007254; P:JNK cascade; TAS:Reactome.
 GO:0071608; P:macrophage inflammatory protein-1 alpha production; IEA:Compara.
 GO:0002282; P:microglial cell activation involved in immune response; IEA:Compara.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Compara.
 GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IEA:Compara.
 GO:0032689; P:negative regulation of interferon-gamma production; IEA:Compara.
 GO:0032695; P:negative regulation of interleukin-12 production; IEA:Compara.
 GO:0032701; P:negative regulation of interleukin-18 production; IEA:Compara.
 GO:0032703; P:negative regulation of interleukin-2 production; IEA:Compara.
 GO:2000110; P:negative regulation of macrophage apoptotic process; ISS:BHF-UCL.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0002710; P:negative regulation of T cell mediated immunity; IEA:Compara.
 GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; IEA:Compara.
 GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Compara.
 GO:0070431; P:nucleotide-binding oligomerization domain containing 2 signaling pathway; IDA:MGI.
 GO:0052033; P:pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; IEA:Compara.
 GO:0050871; P:positive regulation of B cell activation; IDA:BHF-UCL.
 GO:0006965; P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria; IEA:Compara.
 GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; ISS:BHF-UCL.
 GO:0002732; P:positive regulation of dendritic cell cytokine production; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:BHF-UCL.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:BHF-UCL.
 GO:0046645; P:positive regulation of gamma-delta T cell activation; ISS:BHF-UCL.
 GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.
 GO:0050718; P:positive regulation of interleukin-1 beta secretion; IDA:HGNC.
 GO:0032733; P:positive regulation of interleukin-10 production; ISS:BHF-UCL.
 GO:0032735; P:positive regulation of interleukin-12 production; IEA:Compara.
 GO:0032740; P:positive regulation of interleukin-17 production; IMP:UniProtKB.
 GO:0032755; P:positive regulation of interleukin-6 production; IDA:BHF-UCL.
 GO:0046330; P:positive regulation of JNK cascade; IDA:MGI.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; ISS:BHF-UCL.
 GO:0045747; P:positive regulation of Notch signaling pathway; ISS:BHF-UCL.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0050766; P:positive regulation of phagocytosis; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:BHF-UCL.
 GO:2000363; P:positive regulation of prostaglandin-E synthase activity; ISS:BHF-UCL.
 GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; ISS:BHF-UCL.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:BHF-UCL.
 GO:0002830; P:positive regulation of type 2 immune response; IMP:BHF-UCL.
 GO:0051259; P:protein oligomerization; TAS:HGNC.
 GO:0050727; P:regulation of inflammatory response; IC:BHF-UCL.
 GO:0090022; P:regulation of neutrophil chemotaxis; IEA:Compara.
 GO:0043330; P:response to exogenous dsRNA; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
 GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR001315; CARD.
 IPR011029; DEATH-like_dom.
 IPR001611; Leu-rich_rpt.
 IPR007111; NACHT_NTPase.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00619; CARD 
SMART
 SM00114; CARD 
PROSITE
 PS50209; CARD
 PS51450; LRR
 PS50837; NACHT 
PRINTS