| Tag | Content |
|---|
| CPLM ID | CPLM-013546 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Keratin, type I cytoskeletal 18 |
Protein Synonyms/Alias | Cytokeratin-18; CK-18; Keratin-18; K18 |
Gene Name | Krt18 |
Gene Synonyms/Alias | Krt1-18 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 180 | SDIHGLRKVVDDTNI | acetylation | [1] | | 365 | ALLNIKVKLEAEIAT | acetylation | [1] | | 405 | VQRTTTRKVVDGKVV | acetylation | [1] | | 410 | TRKVVDGKVVSETND | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (By similarity). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. |
Sequence Annotation | REGION 2 71 Head.
REGION 62 366 Necessary for interaction with PNN (By
REGION 69 121 Interaction with TRADD (By similarity).
REGION 72 380 Rod.
REGION 72 107 Coil 1A.
REGION 108 125 Linker 1.
REGION 126 217 Coil 1B.
REGION 218 241 Linker 12.
REGION 236 384 Interaction with DNAJB6 (By similarity).
REGION 242 380 Coil 2.
REGION 381 423 Tail.
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 8 8 Phosphothreonine (By similarity).
MOD_RES 11 11 Phosphoserine (By similarity).
MOD_RES 12 12 Phosphothreonine (By similarity).
MOD_RES 16 16 Phosphoserine (By similarity).
MOD_RES 19 19 Phosphoserine.
MOD_RES 31 31 Phosphoserine; alternate (By similarity).
MOD_RES 32 32 Phosphoserine; alternate (By similarity).
MOD_RES 35 35 Phosphoserine.
MOD_RES 37 37 Phosphotyrosine (By similarity).
MOD_RES 43 43 Phosphoserine (By similarity).
MOD_RES 52 52 Phosphoserine; by MAPKAPK2 and MAPKAPK3
MOD_RES 60 60 Phosphoserine (By similarity).
MOD_RES 124 124 N6-acetyllysine (By similarity).
MOD_RES 170 170 Phosphoserine (By similarity).
MOD_RES 295 295 Phosphothreonine (By similarity).
MOD_RES 392 392 Phosphoserine (By similarity).
MOD_RES 394 394 Phosphoserine (By similarity).
MOD_RES 397 397 Phosphothreonine (By similarity).
CARBOHYD 31 31 O-linked (GlcNAc); alternate (By
CARBOHYD 32 32 O-linked (GlcNAc); alternate (By
CARBOHYD 50 50 O-linked (GlcNAc) (By similarity). |
Keyword | Acetylation; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Intermediate filament; Keratin; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 423 AA |
Protein Sequence | MSFTTRSTTF STNYRSLGSV RTPSQRVRPA SSAASVYAGA GGSGSRISVS RSVWGGSVGS 60
AGLAGMGGVQ TEKETMQDLN DRLASYLDKV KNLETENRRL ESKIREYLEK RGPQGVRDWG 120
HYFKTIEDLR AQIFANSVDN ARIVLQIDNA RLAADDFRVK YETELAMRQS VESDIHGLRK 180
VVDDTNITRL QLETEIEALK EELLFMKKNH EEEVQGLEAQ IASSGLTVEV DAPKSQDLSK 240
IMADIRAQYE QLAQKNREEL DKYWSQQIEE STTVVTTKSA EIRDAETTLL ELRRTLQTLE 300
IDLDSMKNQN INLENNLGEV EARYRVQMEQ LNGVLLHLES ELAQTRAEGQ RQTQEYEALL 360
NIKVKLEAEI ATYRRLLEDG DDFSLNDALD SSNSMQTVQR TTTRKVVDGK VVSETNDTRV 420
LRH 423 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |