CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001326
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Discs overgrown protein kinase 
Protein Synonyms/Alias
 Protein double-time 
Gene Name
 dco 
Gene Synonyms/Alias
 dbt; CG2048 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
57HIESKFYKTMQGGIGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. 
Sequence Annotation
 DOMAIN 9 277 Protein kinase.
 NP_BIND 15 23 ATP (By similarity).
 ACT_SITE 128 128 Proton acceptor (By similarity).
 BINDING 38 38 ATP (By similarity).
 MOD_RES 333 333 Phosphoserine.
 MOD_RES 334 334 Phosphoserine.  
Keyword
 ATP-binding; Biological rhythms; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 440 AA 
Protein Sequence
MELRVGNKYR LGRKIGSGSF GDIYLGTTIN TGEEVAIKLE CIRTKHPQLH IESKFYKTMQ 60
GGIGIPRIIW CGSEGDYNVM VMELLGPSLE DLFNFCSRRF SLKTVLLLAD QMISRIDYIH 120
SRDFIHRDIK PDNFLMGLGK KGNLVYIIDF GLAKKFRDAR SLKHIPYREN KNLTGTARYA 180
SINTHLGIEQ SRRDDLESLG YVLMYFNLGA LPWQGLKAAN KRQKYERISE KKLSTSIVVL 240
CKGFPSEFVN YLNFCRQMHF DQRPDYCHLR KLFRNLFHRL GFTYDYVFDW NLLKFGGPRN 300
PQAIQQAQDG ADGQAGHDAV AAAAAVAAAA AASSHQQQQH KVNAALGGGG GSAAQQQLQG 360
GQTLAMLGGN GGGNGSQLIG GNGLNMDDSM AATNSSRPPY DTPERRPSIR MRQGGGGGGG 420
GVGVGGMPSG GGGGGVGNAK 440 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0005886; C:plasma membrane; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:FlyBase.
 GO:0048148; P:behavioral response to cocaine; IMP:FlyBase.
 GO:0008062; P:eclosion rhythm; TAS:FlyBase.
 GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.
 GO:0042067; P:establishment of ommatidial planar polarity; IMP:FlyBase.
 GO:0007446; P:imaginal disc growth; IMP:FlyBase.
 GO:0045475; P:locomotor rhythm; NAS:FlyBase.
 GO:0043066; P:negative regulation of apoptotic process; IMP:FlyBase.
 GO:0051781; P:positive regulation of cell division; IMP:FlyBase.
 GO:0030307; P:positive regulation of cell growth; IMP:FlyBase.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:FlyBase.
 GO:0042306; P:regulation of protein import into nucleus; TAS:FlyBase.
 GO:0030431; P:sleep; NAS:FlyBase.
 GO:0016055; P:Wnt receptor signaling pathway; IMP:FlyBase. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS