CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006780
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator YiaJ 
Protein Synonyms/Alias
 YiaKLMNOPQRS operon repressor; YiaK-S operon repressor 
Gene Name
 yiaJ 
Gene Synonyms/Alias
 b3574; JW3546 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
17ENEMAQEKERPAGSQacetylation[1]
134DHAILIYKLEPTTGMacetylation[1]
173FGHPDYVKSYWESHQacetylation[1]
248SLSTSRLKQVGEKNLacetylation[1]
253RLKQVGEKNLLKPLRacetylation[1]
257VGEKNLLKPLRETAQacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L-gulonate. 
Sequence Annotation
 DOMAIN 23 85 HTH iclR-type.
 DOMAIN 100 272 IclR-ED.
 DNA_BIND 45 64 H-T-H motif (Potential).  
Keyword
 3D-structure; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MGKEVMGKKE NEMAQEKERP AGSQSLFRGL MLIEILSNYP NGCPLAHLSE LAGLNKSTVH 60
RLLQGLQSCG YVTTAPAAGS YRLTTKFIAV GQKALSSLNI IHIAAPHLEA LNIATGETIN 120
FSSREDDHAI LIYKLEPTTG MLRTRAYIGQ HMPLYCSAMG KIYMAFGHPD YVKSYWESHQ 180
HEIQPLTRNT ITELPAMFDE LAHIRESGAA MDREENELGV SCIAVPVFDI HGRVPYAVSI 240
SLSTSRLKQV GEKNLLKPLR ETAQAISNEL GFTVRDDLGA IT 282 
Gene Ontology
 GO:0032993; C:protein-DNA complex; IDA:EcoCyc.
 GO:0003677; F:DNA binding; IDA:EcoCyc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR014757; Tscrpt_reg_IclR_C.
 IPR005471; Tscrpt_reg_IclR_N.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF09339; HTH_IclR
 PF01614; IclR 
SMART
 SM00346; HTH_ICLR 
PROSITE
 PS51077; HTH_ICLR
 PS51078; ICLR_ED 
PRINTS