CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATPase WRNIP1 
Protein Synonyms/Alias
 Werner helicase-interacting protein 1 
Gene Name
 Wrnip1 
Gene Synonyms/Alias
 Whip 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
220IRQMLEGKPLADKMRubiquitination[1]
281HIIANNSKKHSIRFVubiquitination[1]
296TLSATNAKTNDVRDVubiquitination[1]
477LITENDVKEGLQRSHubiquitination[1]
503NCISALHKAMRGSDQubiquitination[1]
596YSAYNNVKACLRSHQubiquitination[1]
622NAPTRLMKDLGYGKGubiquitination[1]
628MKDLGYGKGYKYNPMacetylation[2]
628MKDLGYGKGYKYNPMubiquitination[1]
631LGYGKGYKYNPMYSEubiquitination[1]
656LRGVDFFKQRRC***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity). 
Sequence Annotation
 NP_BIND 263 270 ATP (Potential).
 MOD_RES 75 75 Phosphoserine (By similarity).
 MOD_RES 85 85 Phosphothreonine (By similarity).
 MOD_RES 91 91 Phosphoserine (By similarity).
 MOD_RES 92 92 Phosphoserine.
 MOD_RES 116 116 Phosphothreonine (By similarity).
 MOD_RES 153 153 Phosphoserine.
 MOD_RES 529 529 Phosphotyrosine.
 MOD_RES 557 557 Phosphotyrosine (By similarity).
 MOD_RES 628 628 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; ATP-binding; Complete proteome; DNA damage; DNA replication; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 660 AA 
Protein Sequence
MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP AAGSHRAGER 60
AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD DGGETESRES YDAPPTPSGA 120
RLIPDFPVAR SSSPARKGMG KRPAAAAAAG SASPRSWDEA EAQEEEEAGV DGDGDADVDG 180
EDDPGHWDAD AADASFGVSA GRAHPRALAA EEIRQMLEGK PLADKMRPDT LQDYIGQSRA 240
VGQETLLRSL LEANEIPSLI LWGPPGCGKT TLAHIIANNS KKHSIRFVTL SATNAKTNDV 300
RDVIKQAQNE KSFFKRKTIL FIDEIHRFNK SQQDTFLPHV ECGTITLIGA TTENPSFQVN 360
AALLSRCRVI VLEKLPVEAM VTILMRAINS LGIHVLDSSR PTDPLSHSSN CSSEPSVFIE 420
DKAVDTLAYL SDGDARTGLN GLQLAVLARL SSRKVFCKKS GQTYSPSRVL ITENDVKEGL 480
QRSHILYDRA GEEHYNCISA LHKAMRGSDQ NASLYWLARM LEGGEDPLYV ARRLVRFASE 540
DIGLADPSAL AQAVAAYQGC HFIGMPECEV LLAQCVVYFA RAPKSIEVYS AYNNVKACLR 600
SHQGPLPPVP LHLRNAPTRL MKDLGYGKGY KYNPMYSEPV DQDYLPEELR GVDFFKQRRC 660 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0000731; P:DNA synthesis involved in DNA repair; ISS:UniProtKB.
 GO:0030174; P:regulation of DNA-dependent DNA replication initiation; ISS:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR021886; MgsA_C.
 IPR027417; P-loop_NTPase.
 IPR006642; Znf_Rad18_put. 
Pfam
 PF00004; AAA
 PF12002; MgsA_C 
SMART
 SM00382; AAA
 SM00734; ZnF_Rad18 
PROSITE
 PS00674; AAA 
PRINTS