UniProt Accession

 KITH_MOUSE; P04184; Q58EU0; Q8C3P8; Q921J8 

Genbank Protein ID

 M11945; M19438; M68489; S57244; AK085188; AK087988; AK139244; BC012215; BC091758; X60980; M22581 

Genbank Nucleotide ID

 AAA40451.1; AAA40452.1; AAA40454.1; AAB26001.1; BAC39384.1; BAC40077.1; BAE23931.1; AAH12215.1; AAH91758.1; CAA43296.1; AAA40450.1 

Protein Name

 Thymidine kinase, cytosolic 

Protein Synonyms/Alias

  

Gene Name

 Tk1 

Gene Synonyms/Alias

 Tk-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
16	VLPSSPSKTRGQIQV	ubiquitination	[1]
131	LDGTFQRKAFGSILN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 NP_BIND 26 33 ATP (Probable).
 NP_BIND 58 60 ATP (By similarity).
 NP_BIND 97 100 ATP (By similarity).
 REGION 172 176 Substrate binding (By similarity).
 ACT_SITE 98 98 Proton acceptor (Potential).
 METAL 153 153 Zinc (By similarity).
 METAL 156 156 Zinc (By similarity).
 METAL 185 185 Zinc (By similarity).
 METAL 188 188 Zinc (By similarity).
 BINDING 128 128 Substrate; via amide nitrogen (By
 BINDING 181 181 Substrate (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 13 13 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 233 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004797; F:thymidine kinase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0060138; P:fetal process involved in parturition; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0051414; P:response to cortisol stimulus; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0014856; P:skeletal muscle cell proliferation; IEA:Compara.
 GO:0046104; P:thymidine metabolic process; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR001267; Thymidine_kinase.
 IPR020633; Thymidine_kinase_CS. 

Pfam

 PF00265; TK 

SMART

  

PROSITE

 PS00603; TK_CELLULAR_TYPE 

PRINTS