UniProt Accession

 TIM10_YEAST; P87108; D3DKU9 

Genbank Protein ID

 Z80875; U10555; BK006934 

Genbank Nucleotide ID

 CAB02581.1; AAB68435.1; DAA06693.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit TIM10 

Protein Synonyms/Alias

 Mitochondrial intermembrane protein MRS11 

Gene Name

 TIM10 

Gene Synonyms/Alias

 MRS11; YHR005C-A; YHR005BC 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
42	KLVNNCYKKCINTSY	ubiquitination	[1]
56	YSEGELNKNESSCLD	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor. 

Sequence Annotation

 REGION 1 31 Interaction with transmembrane regions of
 REGION 73 93 Required for heterohexamerization.
 MOTIF 40 65 Twin CX3C motif.
 DISULFID 40 65
 DISULFID 44 61  

Keyword

 3D-structure; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 93 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0042721; C:mitochondrial inner membrane protein insertion complex; IDA:SGD.
 GO:0042719; C:mitochondrial intermembrane space protein transporter complex; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008565; F:protein transporter activity; IDA:SGD.
 GO:0051082; F:unfolded protein binding; IDA:SGD.
 GO:0045039; P:protein import into mitochondrial inner membrane; IDA:SGD. 

Interpro

 IPR027100; Tim10.
 IPR004217; Tim10/DDP_fam_Znf.
 IPR027247; Tim10/Tim12. 

Pfam

 PF02953; zf-Tim10_DDP 

SMART

  

PROSITE

  

PRINTS