UniProt Accession

 Q5L0H6_GEOKA; Q5L0H6 

Genbank Protein ID

 BA000043 

Genbank Nucleotide ID

 BAD75560.1 

Protein Name

 Aspartate-semialdehyde dehydrogenase 

Protein Synonyms/Alias

 ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase 

Gene Name

 asd 

Gene Synonyms/Alias

 GK1275 

Created Date

 July 27, 2013 

Organism

 Geobacillus kaustophilus (strain HTA426) 

NCBI Taxa ID

 235909 

Lysine Modification

Position	Peptide	Type	References
10	GEWWMAQKQYHVAVV	acetylation	[1]

Reference

 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 

Functional Description

 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity). 

Sequence Annotation

 NP_BIND 20 23 NADP (By similarity).
 NP_BIND 48 49 NADP (By similarity).
 NP_BIND 167 168 NADP (By similarity).
 ACT_SITE 137 137 Acyl-thioester intermediate (By
 ACT_SITE 257 257 Proton acceptor (By similarity).
 BINDING 108 108 Phosphate (By similarity).
 BINDING 164 164 Substrate (By similarity).
 BINDING 250 250 Substrate (By similarity).
 BINDING 331 331 NADP (By similarity).  

Keyword

 Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Lysine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:HAMAP.
 GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:HAMAP.
 GO:0071266; P:'de novo' L-methionine biosynthetic process; IEA:HAMAP.
 GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP.
 GO:0009097; P:isoleucine biosynthetic process; IEA:InterPro.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP.
 GO:0009088; P:threonine biosynthetic process; IEA:HAMAP. 

Interpro

 IPR000319; Asp-semialdehyde_DH_CS.
 IPR012080; Asp_semialdehyde_DH.
 IPR005986; Asp_semialdehyde_DH_beta.
 IPR016040; NAD(P)-bd_dom.
 IPR000534; Semialdehyde_DH_NAD-bd.
 IPR012280; Semialdhyde_DH_dimer_dom. 

Pfam

 PF01118; Semialdhyde_dh
 PF02774; Semialdhyde_dhC 

SMART

 SM00859; Semialdhyde_dh 

PROSITE

 PS01103; ASD 

PRINTS