CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018607
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidate phosphatase LPIN1 
Protein Synonyms/Alias
 Fatty liver dystrophy protein; Lipin-1 
Gene Name
 Lpin1 
Gene Synonyms/Alias
 Fld 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
599RGRNATIKEESKPEQsumoylation[1]
629LGLATRIKHESSSSDsumoylation[1]
Reference
 [1] Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.
 Liu GH, Gerace L.
 PLoS One. 2009 Sep 15;4(9):e7031. [PMID: 19753306] 
Functional Description
 Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. 
Sequence Annotation
 REGION 1 108 N-LIP.
 REGION 658 864 C-LIP.
 MOTIF 153 158 Nuclear localization signal (Potential).
 MOTIF 712 716 DXDXT motif.
 MOTIF 723 727 LXXIL motif.
 MOD_RES 106 106 Phosphoserine.
 MOD_RES 150 150 Phosphoserine.
 MOD_RES 285 285 Phosphoserine.
 MOD_RES 287 287 Phosphoserine.
 MOD_RES 293 293 Phosphoserine.
 MOD_RES 298 298 Phosphothreonine.
 MOD_RES 328 328 Phosphoserine.
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 468 468 Phosphoserine.
 MOD_RES 472 472 Phosphoserine.
 MOD_RES 483 483 Phosphoserine.
 MOD_RES 634 634 Phosphoserine.
 MOD_RES 635 635 Phosphoserine.
 MOD_RES 921 921 Phosphoserine.
 MOD_RES 923 923 Phosphoserine.
 CROSSLNK 599 599 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 629 629 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Hydrolase; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 924 AA 
Protein Sequence
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GSLQCSPFHV RFGKMGVLRS 60
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEIIP MYLATSPILS EGAARMESQL 120
KRNSVDRIRC LDPTTAAQGL PPSDTPSTGS LGKKRRKRRR KAQLDNLKRD DNVNSSEDED 180
MFPIEMSSDE DTAPMDGSRT LPNDVPPFQD DIPKENFPSI STHPQSASYP SSDREWSPSP 240
SSLVDCQRTP PHLAEGVLSS SCPLQSCHFH ASESPSGSRP STPKSDSELV SKSADRLTPK 300
NNLEMLWLWG ELPQAAKSSS PHKMKESSPL GSRKTPDKMN FQAIHSESSD TFSDQSPTMA 360
RGLLIHQSKA QTEMQFVNEE DLESLGAAAP PSPVAEELKA PYPNTAQSSS KTDSPSRKKD 420
KRSRHLGADG VYLDDLTDMD PEVAALYFPK NGDPGGLPKQ ASDNGARSAN QSPQSVGGSG 480
IDSGVESTSD SLRDLPSIAI SLCGGLSDHR EITKDAFLEQ AVSYQQFADN PAIIDDPNLV 540
VKVGNKYYNW TTAAPLLLAM QAFQKPLPKA TVESIMRDKM PKKGGRWWFS WRGRNATIKE 600
ESKPEQCLTG KGHNTGEQPA QLGLATRIKH ESSSSDEEHA AAKPSGSSHL SLLSNVSYKK 660
TLRLTSEQLK SLKLKNGPND VVFSVTTQYQ GTCRCEGTIY LWNWDDKVII SDIDGTITRS 720
DTLGHILPTL GKDWTHQGIA KLYHKVSQNG YKFLYCSARA IGMADMTRGY LHWVNERGTV 780
LPQGPLLLSP SSLFSALHRE VIEKKPEKFK VQCLTDIKNL FFPNTEPFYA AFGNRPADVY 840
SYKQVGVSLN RIFTVNPKGE LVQEHAKTNI SSYVRLCEVV DHVFPLLKRS HSCDFPCSDT 900
FSNFTFWREP LPPFENQDMH SASA 924 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0042826; F:histone deacetylase binding; IDA:MGI.
 GO:0008195; F:phosphatidate phosphatase activity; IDA:MGI.
 GO:0001085; F:RNA polymerase II transcription factor binding; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; IMP:MGI.
 GO:0032869; P:cellular response to insulin stimulus; IMP:MGI.
 GO:0045444; P:fat cell differentiation; NAS:UniProtKB.
 GO:0009062; P:fatty acid catabolic process; IDA:UniProtKB.
 GO:0006629; P:lipid metabolic process; IMP:MGI.
 GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0031065; P:positive regulation of histone deacetylation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0045598; P:regulation of fat cell differentiation; IMP:MGI.
 GO:0031529; P:ruffle organization; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006642; P:triglyceride mobilization; IDA:UniProtKB. 
Interpro
 IPR023214; HAD-like_dom.
 IPR026058; LIPIN.
 IPR007651; Lipin_N.
 IPR013209; LNS2. 
Pfam
 PF04571; Lipin_N
 PF08235; LNS2 
SMART
 SM00775; LNS2 
PROSITE
  
PRINTS