CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Shroom3 
Protein Synonyms/Alias
  
Gene Name
 Shroom3 
Gene Synonyms/Alias
 Kiaa1481; Shrm 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1247SSPTSDKKGQDVLLRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays. 
Sequence Annotation
 DOMAIN 24 109 PDZ.
 DOMAIN 927 1023 ASD1.
 DOMAIN 1659 1947 ASD2.
 MOD_RES 439 439 Phosphoserine.
 MOD_RES 443 443 Phosphoserine.
 MOD_RES 888 888 Phosphoserine.
 MOD_RES 909 909 Phosphothreonine.
 MOD_RES 912 912 Phosphoserine (By similarity).
 MOD_RES 969 969 Phosphoserine (By similarity).
 MOD_RES 1219 1219 Phosphoserine (By similarity).  
Keyword
 Actin-binding; Alternative splicing; Cell junction; Cell shape; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Direct protein sequencing; Microtubule; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1986 AA 
Protein Sequence
MKTPENLEEP SATPNPSRTP TERFVYLEAL LEGGAPWGFT LKGGLERGEP LIISKIEEGG 60
KADSVSSGLQ AGDEVIHINE VALSSPRREA VSLVKGSYKT LRLVVRRDVC AAPGHADPGT 120
SKSLSSELLT CSPQHRKATW SGGVKLRLKQ RCSEPATRPH SWHTTKFGET QPDVSMMQIS 180
QGTMGPPWHQ SYHSSSSTSD LSNYDHAYLR RSPDQCSSQG SMESLEPSGG YPPCHLLSPA 240
KSTSSIDQLG HLHNKRDSAY SSFSTSSSIF EYPPPGGSAR ERSGSMDVIS ARGGLLEGMR 300
QADIRYVKTV YDTRRGVSSE YEVNPSALLL QGRDAHASAD SQGCAKWHSI PRGKGTPSPS 360
WSQQCSGSLE TATDNLPQKA GAPLPPTRSD SYAAFRHRER PSSWSSLDQK RFCRPQTNSS 420
GSQKTPFAED QLHTVPERSP ENSPPVKSKH NYTQKAQPGQ PLLPTGIYPV PSPEPHFAQV 480
PQPSVSSNGT VYPALVKESG YTAAQGTCNK MATLDENGNQ NEASRPGFAF CQPLEHNSVT 540
PVEKRPEPTA KYIYKVHFSS VPENEDSSLK RHITPPHGHS PYPSERKNIH GGSRACSNHH 600
SLSSPQAQAL HVGDDRRPSR LSQPWEGDFQ EDHNANLRQK VEREGQGQGL SGNSGRTRSA 660
FSSLQNIPES LRRQSNVELG EAQEVHPGGR SKVEDPGRKA GASDIRGYLD RSVSYPRPEG 720
KMNAVDSVHS ADSRYEESPA PALPQTSGAS QRRLSSSSSA APQYRKPHCS VLEKVSRIEE 780
REQGRHRPLS VGSSAYGPGY RPGRTGPTPS TSSSDLDDPK AGSVHFSEST EHLRNGEQNP 840
PNGEAKQEEA SRPQCSHLIR RAPADGRGPP ARGGEPSRPE ARLLRSQSTF QLYSEAEREA 900
SWSEDRPGTP ESPLLDAPFS RAYRNSIKDA QSRVLGATSF RRRDLEPGTP ATSRPWRPRP 960
ASAHVGMRSP EAAVPSSSPH TPRERHSVTP AAPQAARRGP RRRLTVEQKK RSYSEPEKMN 1020
EVGVSEEAEP TPCGPPRPAQ PRFSESTVAD RRRIFERDGK ACSTLSLSGP ELKQFQQSAL 1080
ADYIQRKTGK RPTGAACTPE AGLRERAQSA YLQAGPAAPD GPGLASACSL SSLREPEALP 1140
RKEHTHPSAA DGPQAPRDRS SSFASGRLVG ERRRWDPQVP RQLLSGANCE PRGVQRMDGA 1200
PGGPPSWGMV AGKAGKSKSA EDLLERSDTL AVPVHVRSRS SPTSDKKGQD VLLREGSNFG 1260
FVKDPCCLAG PGPRSLSCSD KGQNELALPL HHPTPCWNGS GCKATVASSA PPESSGAADH 1320
LKQRRAPGPR PLSAGMHGHF PDARAASLSS PLPSPVPSAS PVPSSYRSQL AMDQQTGQQP 1380
PSSPASAVTQ PTSPRSPELS SPAYGLGEGM WKRTSLPQRP PPPWVKWAHA VREDGLAEDT 1440
LAPEFANLKH YRNQPSRPSS CSTSDPDTPG RISLRISESA LQPSPPPRGD YDDEVFMKDL 1500
HPKVTSSPTF EALPPPPPPS PPSEEPLVNG TDDFPPPPPP QALCEVLLDG EASTEAGSGP 1560
CRIPRVMVTR EGHVPGAAHS EGSQIMTATP PQTSAKGSEA ESNTPSSASA QPQLNGSPGK 1620
QLCPSQTRNL TYEPVERTQD LGKKTHAEPQ KTSEDIRTEA LAKEIVHQDK SLADILDPDS 1680
RMKTTMDLME GLFPGDASVL MDSGAKRKAL DITARRAGCE AKASDHKEAV SVLVNCPAYY 1740
SVSAAKAELL NKIKDMPEEL QEEEGQEDVN EKKAELIGSL THKLESLQEA KGSLLTDIKL 1800
NNALGEEVEA LISELCKPNE FDKYKMFIGD LDKVVNLLLS LSGRLARVEN VLRGLGEDAS 1860
KEERSSLNEK RKVLAGQHED ARELKENLDR RERVVLDILA NYLSAEQLQD YQHFVKMKST 1920
LLIEQRKLDD KIKLGQEQVR CLLESLPSDF RPKAGAISLP PALTGHATPG GTSVFGGVFP 1980
TLTSPL 1986 
Gene Ontology
 GO:0005912; C:adherens junction; IDA:MGI.
 GO:0043296; C:apical junction complex; IDA:MGI.
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IDA:MGI.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IGI:MGI.
 GO:0045176; P:apical protein localization; ISS:HGNC.
 GO:0000902; P:cell morphogenesis; ISS:HGNC.
 GO:0043482; P:cellular pigment accumulation; ISS:HGNC.
 GO:0002066; P:columnar/cuboidal epithelial cell development; IDA:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0007389; P:pattern specification process; IMP:MGI.
 GO:0008360; P:regulation of cell shape; IDA:MGI. 
Interpro
 IPR014800; ASD1.
 IPR014799; ASD2.
 IPR001478; PDZ. 
Pfam
 PF08688; ASD1
 PF08687; ASD2
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS51306; ASD1
 PS51307; ASD2
 PS50106; PDZ 
PRINTS