CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028242
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GH13256p 
Protein Synonyms/Alias
 Thiolase 
Gene Name
 Thiolase 
Gene Synonyms/Alias
 CG4581; Dmel_CG4581 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
63TSGTTYSKLMPHELAacetylation[1]
175KMRSLLLKANKAKTLacetylation[1]
268GVDQIVDKDNGIRVSacetylation[1]
282SSPESLAKLRPAFVKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Oxidoreductase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MSLQNVCRKG NAFNLLNVAR KVQCRALSAA VANPQPKQKN SQNIVLVDGV RTPFLTSGTT 60
YSKLMPHELA RHSLLSLLQK NRLDKELIDY IVYGSVIQEV KTSNIAREAA LAAGFSNKTP 120
AHTVTMACIS SNAAITTGMG LIATNTYDVI VAGGVEFMSD VPIRHSRKMR SLLLKANKAK 180
TLGQRLALLS TFRPDFLAPE LPAVAEFSSG ETMGHSADRL ASAFNVSRSE QDEYALRSHT 240
LAKEAQEKGY FTDLVPFKVS GVDQIVDKDN GIRVSSPESL AKLRPAFVKP YGTVTAANAS 300
FLTDGASACI IMTEEKAKQL GLKPKAYLRD FLFVSQDPVN QLLLGPAYGI PKLLKKAGLT 360
LKDIDSWEIH EAFAGQIVAN LKALDSDWFC KTYLGLNEKV GTPDLSKWNN WGGSLSIGHP 420
FAATGVRLCM HTANRLVRED GKLGVVAACA AGGQGVAMLI ERYPGATAD 469 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:EC.
 GO:0016509; F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity; IEA:EC.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0006635; P:fatty acid beta-oxidation; IMP:FlyBase. 
Interpro
 IPR002155; Thiolase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020615; Thiolase_acyl_enz_int_AS.
 IPR020610; Thiolase_AS.
 IPR020617; Thiolase_C.
 IPR020613; Thiolase_CS.
 IPR020616; Thiolase_N. 
Pfam
 PF02803; Thiolase_C
 PF00108; Thiolase_N 
SMART
  
PROSITE
 PS00098; THIOLASE_1
 PS00737; THIOLASE_2
 PS00099; THIOLASE_3 
PRINTS