UniProt Accession

 PRDX5_RAT; Q9R063; Q68G22 

Genbank Protein ID

 AF110732; BC078771 

Genbank Nucleotide ID

 AAF03751.1; AAH78771.1 

Protein Name

 Peroxiredoxin-5, mitochondrial 

Protein Synonyms/Alias

 Antioxidant enzyme B166; AOEB166; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; Thioredoxin peroxidase PMP20; Thioredoxin reductase 

Gene Name

 Prdx5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
56	AVTMAPIKVGDTIPS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling (By similarity). 

Sequence Annotation

 DOMAIN 55 213 Thioredoxin.
 MOTIF 211 213 Microbody targeting signal (By
 ACT_SITE 99 99 Cysteine sulfenic acid (-SOH)
 MOD_RES 82 82 N6-acetyllysine (By similarity).
 DISULFID 99 203 Redox-active (By similarity).  

Keyword

 Acetylation; Alternative initiation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Mitochondrion; Oxidoreductase; Peroxidase; Peroxisome; Polymorphism; Redox-active center; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:HGNC.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Compara.
 GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
 GO:0072541; F:peroxynitrite reductase activity; IEA:Compara.
 GO:0001016; F:RNA polymerase III regulatory region DNA binding; IEA:Compara.
 GO:0042744; P:hydrogen peroxide catabolic process; IEA:Compara.
 GO:0070995; P:NADPH oxidation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0051354; P:negative regulation of oxidoreductase activity; IEA:Compara.
 GO:0016480; P:negative regulation of transcription from RNA polymerase III promoter; IEA:Compara.
 GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Compara.
 GO:2001057; P:reactive nitrogen species metabolic process; IEA:Compara.
 GO:0060785; P:regulation of apoptosis involved in tissue homeostasis; IEA:Compara. 

Interpro

 IPR013740; Redoxin.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF08534; Redoxin 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS